Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science.
Drosophila
genomics
metabolomics
toxicodynamics
toxicokinetics
Journal
Current protocols
ISSN: 2691-1299
Titre abrégé: Curr Protoc
Pays: United States
ID NLM: 101773894
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
pmc-release:
01
08
2024
medline:
31
8
2023
pubmed:
28
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
The use of Drosophila melanogaster for studies of toxicology has grown considerably in the last decade. The Drosophila model has long been appreciated as a versatile and powerful model for developmental biology and genetics because of its ease of handling, short life cycle, low cost of maintenance, molecular genetic accessibility, and availability of a wide range of publicly available strains and data resources. These features, together with recent unique developments in genomics and metabolomics, make the fly model especially relevant and timely for the development of new approach methodologies and movements toward precision toxicology. Here, we offer a perspective on how flies can be leveraged to identify risk factors relevant to environmental exposures and human health. First, we review and discuss fundamental toxicologic principles for experimental design with Drosophila. Next, we describe quantitative and systems genetics approaches to resolve the genetic architecture and candidate pathways controlling susceptibility to toxicants. Finally, we summarize the current state and future promise of the emerging field of Drosophila metabolomics for elaborating toxic mechanisms. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.
Identifiants
pubmed: 37639638
doi: 10.1002/cpz1.870
pmc: PMC10463236
mid: NIHMS1923369
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e870Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030940
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007026
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM139769
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025721
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM128974
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES001247
Pays : United States
Informations de copyright
© 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.
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