Schwann cell derived-peroxiredoxin protects motor neurons against hydrogen peroxide-induced cell death in mouse motor neuron cell line NSC-34.
Amyotrophic lateral sclerosis
Peroxiredoxin
Reactive oxygen species
Schwann cells
Journal
Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
19
04
2023
revised:
26
07
2023
accepted:
28
07
2023
medline:
31
8
2023
pubmed:
29
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
Schwann cells and oligodendrocytes secrete proteins that promote neuron survival, but their role in amyotrophic lateral sclerosis (ALS) is unclear. To address this question, we evaluated the effect of molecules secreted by Schwann cells on reactive oxygen species (ROS)-induced motor neuronal cell death. We observed that in motor neuron cell line NSC-34 cultures, the conditioned medium (CM) from Schwann cell line YST-1 (YST-1 CM) cultures had a protective effect against hydrogen peroxide-induced cell death. However, this protective effect of YST-1 CM was abolished by removing peroxiredoxin 1-4 (PRDX1-4) from the CM. We found that the expression of PRDX1 mRNA was markedly downregulated in the lumbar spinal cord of the superoxide dismutase 1 (SOD1)
Identifiants
pubmed: 37640472
pii: S1347-8613(23)00044-0
doi: 10.1016/j.jphs.2023.07.006
pii:
doi:
Substances chimiques
Hydrogen Peroxide
BBX060AN9V
Reactive Oxygen Species
0
Superoxide Dismutase-1
EC 1.15.1.1
Peroxiredoxins
EC 1.11.1.15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-83Informations de copyright
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Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no relevant financial or non-financial interests to disclose.