Notch Signaling Plays a Dual Role in Regulating the Neuron-to-Oligodendrocyte Switch in the Developing Dorsal Forebrain.
ascl1
cell fate
cortex
hes
notch
oligodendrocyte
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
11 10 2023
11 10 2023
Historique:
received:
24
01
2023
revised:
26
07
2023
accepted:
17
08
2023
pmc-release:
11
04
2024
medline:
6
11
2023
pubmed:
29
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
Neural progenitor cells in the developing dorsal forebrain generate excitatory neurons followed by oligodendrocytes (OLs) and astrocytes. However, the specific mechanisms that regulate the timing of this neuron-glia switch are not fully understood. In this study, we show that the proper balance of Notch signaling in dorsal forebrain progenitors is required to generate oligodendrocytes during late stages of embryonic development. Using
Identifiants
pubmed: 37640551
pii: JNEUROSCI.0144-23.2023
doi: 10.1523/JNEUROSCI.0144-23.2023
pmc: PMC10573779
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Receptors, Notch
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6854-6871Subventions
Organisme : NINDS NIH HHS
ID : F31 NS129289
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS109239
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046934
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136444
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109239
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS124166
Pays : United States
Informations de copyright
Copyright © 2023 the authors.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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