Candida-bacterial cross-kingdom interactions.
Candida albicans
antifungal immunity
cross-kingdom interactions
polymicrobial infection
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
29
05
2023
revised:
14
07
2023
accepted:
02
08
2023
medline:
16
11
2023
pubmed:
29
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
While the fungus Candida albicans is a common colonizer of healthy humans, it is also responsible for mucosal infections and severe invasive disease. Understanding the mechanisms that allow C. albicans to exist as both a benign commensal and as an invasive pathogen have been the focus of numerous studies, and recent findings indicate an important role for cross-kingdom interactions on C. albicans biology. This review highlights how C. albicans-bacteria interactions influence healthy polymicrobial community structure, host immune responses, microbial pathogenesis, and how dysbiosis may lead to C. albicans infection. Finally, we discuss how cross-kingdom interactions represent an opportunity to identify new antivirulence compounds that target fungal infections.
Identifiants
pubmed: 37640601
pii: S0966-842X(23)00230-5
doi: 10.1016/j.tim.2023.08.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1287-1299Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145992
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI161022
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.