Tumor-specific cholinergic CD4
Journal
Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
28
09
2021
accepted:
26
07
2023
medline:
27
10
2023
pubmed:
29
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
Cholinergic nerves are involved in tumor progression and dissemination. In contrast to other visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It remains unclear whether there is any form of cholinergic regulation of liver cancer. Here, we show that cholinergic T cells curtail the development of liver cancer by supporting antitumor immune responses. In a mouse multihit model of hepatocellular carcinoma (HCC), we observed activation of the adaptive immune response and induction of two populations of CD4
Identifiants
pubmed: 37640929
doi: 10.1038/s43018-023-00624-w
pii: 10.1038/s43018-023-00624-w
pmc: PMC10597839
doi:
Substances chimiques
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1437-1454Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : 143268
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : 488053
Informations de copyright
© 2023. The Author(s).
Références
Nature. 2014 Oct 16;514(7522):380-4
pubmed: 25119044
Nat Rev Cancer. 2009 Mar;9(3):195-205
pubmed: 19194381
Biochim Biophys Acta. 2010 Apr;1802(4):416-31
pubmed: 20060897
Nature. 2021 Apr;592(7854):450-456
pubmed: 33762733
Cell Metab. 2021 Mar 2;33(3):666-675.e4
pubmed: 33545051
Nature. 2015 Apr 30;520(7549):692-6
pubmed: 25901682
Clin Cancer Res. 2007 Feb 1;13(3):902-11
pubmed: 17289884
Science. 2013 Jul 12;341(6142):1236361
pubmed: 23846904
Cancer. 2003 Apr 15;97(8):1929-40
pubmed: 12673720
Science. 2019 Feb 8;363(6427):639-644
pubmed: 30733420
Science. 2011 Mar 25;331(6024):1565-70
pubmed: 21436444
FEBS Lett. 2006 Sep 18;580(21):4979-83
pubmed: 16938295
Nature. 2019 Mar;567(7749):530-534
pubmed: 30814732
Nature. 2021 Apr;592(7854):444-449
pubmed: 33762736
Science. 2011 Oct 7;334(6052):98-101
pubmed: 21921156
Nature. 2007 Nov 1;450(7166):56-62
pubmed: 17972876
Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415
pubmed: 31152140
Cell. 2017 Feb 9;168(4):613-628
pubmed: 28187284
J Immunol. 1999 Nov 15;163(10):5211-8
pubmed: 10553041
Life Sci. 2016 Sep 15;161:45-50
pubmed: 27474128
Nature. 2011 Nov 09;479(7374):547-51
pubmed: 22080947
Blood. 2010 Apr 15;115(15):2989-97
pubmed: 20103781
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Cell. 2019 Oct 31;179(4):829-845.e20
pubmed: 31675496
Cell. 2017 Jun 15;169(7):1327-1341.e23
pubmed: 28622513
Int J Biol Sci. 2011;7(5):651-8
pubmed: 21647333
Nat Med. 2007 Oct;13(10):1248-52
pubmed: 17891146
Cell Death Differ. 2023 Feb;30(2):407-416
pubmed: 36528755
PLoS One. 2014 May 06;9(5):e96801
pubmed: 24802416
Cancer Res. 2009 Apr 1;69(7):2775-82
pubmed: 19276364
Cancer Cell. 2014 Oct 13;26(4):549-64
pubmed: 25314080
Immunity. 2015 Feb 17;42(2):265-278
pubmed: 25680272
Front Immunol. 2019 Apr 30;10:946
pubmed: 31114585
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3078-83
pubmed: 26929329
Cell Rep. 2021 Nov 2;37(5):109932
pubmed: 34731613
Liver. 1998 Oct;18(5):352-9
pubmed: 9831365
Gastroenterology. 2015 Oct;149(5):1226-1239.e4
pubmed: 26099527
Immunity. 2020 Jan 14;52(1):151-166.e6
pubmed: 31924474
J Biol Chem. 1989 Jan 5;264(1):205-12
pubmed: 2783316
Hepatology. 2012 Oct;56(4):1331-41
pubmed: 22505225
Gastroenterology. 2007 Jun;132(7):2328-39
pubmed: 17570208
Immunity. 2016 Aug 16;45(2):389-401
pubmed: 27521269
Nature. 2019 Mar;567(7749):525-529
pubmed: 30814730
Nature. 2019 Jul;571(7764):211-218
pubmed: 31207603
Front Immunol. 2017 Sep 06;8:1085
pubmed: 28932225
Nat Rev Drug Discov. 2007 Sep;6(9):721-33
pubmed: 17762886
J Autoimmun. 2010 Feb;34(1):1-6
pubmed: 19717280
Nat Genet. 2009 Jun;41(6):753-61
pubmed: 19412179
J Clin Invest. 2004 Jun;113(12):1774-83
pubmed: 15199412
J Immunol. 1994 Jun 1;152(11):5226-40
pubmed: 8189045
NPJ Precis Oncol. 2018 Feb 23;2(1):6
pubmed: 29872724
Cell. 2017 Jun 15;169(7):1342-1356.e16
pubmed: 28622514
Cell Mol Immunol. 2013 May;10(3):230-52
pubmed: 23604045
Front Immunol. 2018 May 04;9:847
pubmed: 29780381
Nature. 2007 Feb 8;445(7128):656-60
pubmed: 17251933
Science. 2013 Feb 15;339(6121):819-23
pubmed: 23287718
Nat Rev Immunol. 2012 Jun 15;12(7):532-47
pubmed: 22699833
Anat Embryol (Berl). 1992 Oct;186(5):431-42
pubmed: 1280009
Nat Med. 2011 Jul 24;17(8):975-82
pubmed: 21785433
Sci Transl Med. 2014 Aug 20;6(250):250ra115
pubmed: 25143365
J Clin Gastroenterol. 2013 Jul;47 Suppl:S2-6
pubmed: 23632345