Perspectives on long-acting formulations of pre-exposure prophylaxis (PrEP) among men who have sex with men who are non-adherent to daily oral PrEP in the United States.
HIV prevention
Medication adherence
Men who have sex with men (MSM)
PrEP continuum
Pre-exposure prophylaxis (PrEP)
Journal
BMC public health
ISSN: 1471-2458
Titre abrégé: BMC Public Health
Pays: England
ID NLM: 100968562
Informations de publication
Date de publication:
28 08 2023
28 08 2023
Historique:
received:
02
07
2022
accepted:
25
07
2023
medline:
31
8
2023
pubmed:
29
8
2023
entrez:
28
8
2023
Statut:
epublish
Résumé
Pre-exposure prophylaxis (PrEP) persistence among men who have sex with men (MSM) in real world clinical settings for HIV prevention is suboptimal. New longer-acting formulations of PrEP are becoming available, including injectables, subdermal implants, and other oral medications. These longer-acting formulations have the potential to improve retention among those who have challenges remaining adherent to daily oral PrEP. We interviewed 49 MSM who had initiated but discontinued oral PrEP at three diverse clinics across the United States. We examined participants' perspectives about long-acting PrEP formulations and how long-acting options could affect PrEP use using thematic analysis. Participants were not very knowledgeable about long-acting formulations of PrEP but were open to learning about them and considering use. Participants were concerned about safety and efficacy of products given that they were still newer and/or in development. Finally, participants had clear preferences for oral pills, injectables, and then subdermal implants and were most interested in options that reduced the number of visits to the clinic. Long-acting formulations of PrEP are acceptable to MSM with suboptimal PrEP persistence and have the potential to improve PrEP persistence. However, many felt they needed more information on safety, efficacy, and use to consider these options. As these long-acting formulations are implemented, public health campaigns and clinical interventions to encourage may maximize uptake particularly among those who are not currently adherent to daily oral PrEP.
Identifiants
pubmed: 37641018
doi: 10.1186/s12889-023-16382-4
pii: 10.1186/s12889-023-16382-4
pmc: PMC10463714
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1643Subventions
Organisme : NIMH NIH HHS
ID : R01 MH114657
Pays : United States
Organisme : NIMH NIH HHS
ID : 5R01MH114657-02
Pays : United States
Organisme : NIMH NIH HHS
ID : L30 MH123946
Pays : United States
Organisme : NIMH NIH HHS
ID : K23MH124539-01A1
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH124539
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI042853
Pays : United States
Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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