Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
02 10 2023
02 10 2023
Historique:
pmc-release:
29
02
2024
medline:
31
8
2023
pubmed:
29
8
2023
entrez:
29
8
2023
Statut:
ppublish
Résumé
In this issue of JEM, companion articles from Pinilla et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230104) and Robinson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230105) demonstrate that ribotoxic stress induced by Pseudomonas aeruginosa and Corynebacterium diphtheriae EEF2-targeting exotoxins leads to NLRP1 inflammasome activation, representing a new mechanism of effector-triggered immunity.
Identifiants
pubmed: 37642998
pii: 276217
doi: 10.1084/jem.20231160
pmc: PMC10465322
pii:
doi:
Substances chimiques
Exotoxins
0
Inflammasomes
0
NLRP1 protein, human
0
NLR Proteins
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM136534
Pays : United States
Commentaires et corrections
Type : CommentOn
Type : CommentOn
Informations de copyright
© 2023 Tibble et al.
Déclaration de conflit d'intérêts
Disclosures: The authors declare no competing financial interests.
Références
Cell Host Microbe. 2009 Jul 23;6(1):10-21
pubmed: 19616762
Nat Microbiol. 2020 Jan;5(1):14-26
pubmed: 31857733
J Exp Med. 2022 Jan 3;219(1):
pubmed: 34910085
Annu Rev Immunol. 2023 Apr 26;41:453-481
pubmed: 36750319