Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis.
inflammation
interstitial lung diseases
platelets
pulmonary fibrosis
transforming growth factor-β1
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
medline:
13
11
2023
pubmed:
29
8
2023
entrez:
29
8
2023
Statut:
ppublish
Résumé
Transforming growth factor-β1 (TGFβ1) is the key profibrotic cytokine in idiopathic pulmonary fibrosis (IPF), but the primary source of this cytokine in this disease is unknown. Platelets have abundant stores of TGFβ1, although the role of these cells in IPF is ill-defined. In this study, we investigated whether platelets, and specifically platelet-derived TGFβ1, mediate IPF disease progression. Patients with IPF and non-IPF patients were recruited to determine platelet reactivity, and separate cohorts of patients with IPF were followed for mortality. To study whether platelet-derived TGFβ1 modulates pulmonary fibrosis (PF), mice with a targeted deletion of TGFβ1 in megakaryocytes and platelets (TGFβ1
Identifiants
pubmed: 37643008
doi: 10.1152/ajplung.00227.2022
pmc: PMC10639018
doi:
Substances chimiques
Transforming Growth Factor beta1
0
Transforming Growth Factor beta
0
Bleomycin
11056-06-7
Transforming Growth Factors
76057-06-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
L487-L499Subventions
Organisme : Medical Research Council
ID : G0800340
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K004158/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V002538/1
Pays : United Kingdom
Références
Am J Respir Crit Care Med. 2003 Aug 15;168(4):431-5
pubmed: 12746254
J Leukoc Biol. 2015 May;97(5):975-984
pubmed: 25717148
Am J Respir Crit Care Med. 2005 Jun 1;171(11):1279-85
pubmed: 15735062
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 33079726
Chest. 2008 Jan;133(1):226-32
pubmed: 18071016
Clin Appl Thromb Hemost. 2016 May;22(4):346-50
pubmed: 26659450
Blood. 2004 Mar 15;103(6):2096-104
pubmed: 14630798
Anal Biochem. 1994 Feb 1;216(2):276-84
pubmed: 8179182
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4584-7
pubmed: 6945600
Eur Respir J. 2022 May 5;59(5):
pubmed: 34561295
Am J Pathol. 2007 Jan;170(1):65-74
pubmed: 17200183
PLoS One. 2018 Dec 31;13(12):e0209786
pubmed: 30596712
N Engl J Med. 2015 Mar 26;372(13):1189-91
pubmed: 25806913
Lung. 2020 Oct;198(5):821-827
pubmed: 32844257
Science. 2014 Dec 5;346(6214):1234-8
pubmed: 25477463
Blood. 2013 Feb 7;121(6):1008-15
pubmed: 23243271
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1809-13
pubmed: 287022
Eur Respir J. 2013 Dec;42(6):1633-45
pubmed: 23520313
J Gastroenterol Hepatol. 2009 Jan;24(1):78-89
pubmed: 18624898
J Pharmacol Toxicol Methods. 2021 May-Jun;109:107057
pubmed: 33819606
Am J Pathol. 1995 Aug;147(2):352-61
pubmed: 7543734
Platelets. 2014;25(4):252-6
pubmed: 23855408
Eur Respir J. 2021 Sep 29;59(4):
pubmed: 34588192
PLoS One. 2014 Oct 22;9(10):e111347
pubmed: 25338090
Int J Exp Pathol. 1994 Oct;75(5):321-8
pubmed: 7528044
J Cell Commun Signal. 2021 Mar;15(1):7-23
pubmed: 33481173
Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3053-61
pubmed: 25024172
Nature. 2017 Apr 6;544(7648):105-109
pubmed: 28329764
Blood Adv. 2018 Mar 13;2(5):470-480
pubmed: 29490978
Am J Physiol Lung Cell Mol Physiol. 2000 Oct;279(4):L658-66
pubmed: 11000125
Cancer Cell. 2011 Nov 15;20(5):576-90
pubmed: 22094253
Thorax. 2001 Dec;56(12):907-15
pubmed: 11713352
Cell Death Dis. 2019 Sep 9;10(9):648
pubmed: 31501415
Anal Biochem. 1990 May 1;186(2):257-63
pubmed: 2363497
Exp Lung Res. 2015 Mar;41(2):57-73
pubmed: 25514507
PLoS One. 2018 Mar 16;13(3):e0193057
pubmed: 29547661
J Exp Med. 1989 Sep 1;170(3):727-37
pubmed: 2475572
Clin Med (Lond). 2016 Dec;16(Suppl 6):s71-s78
pubmed: 27956445
J Cell Biol. 1993 Jul;122(1):103-11
pubmed: 8314838
Sci Transl Med. 2018 Sep 26;10(460):
pubmed: 30257954
J Exp Med. 2020 Feb 13;217(3):e20190103
pubmed: 32997468
Respir Res. 2003;4:13
pubmed: 14624704
J Biol Chem. 1983 Jun 10;258(11):7155-60
pubmed: 6602130
J Pathol. 2014 Jul;233(3):294-307
pubmed: 24740698
Eur Respir Rev. 2021 Sep 15;30(161):
pubmed: 34526315
Am J Respir Cell Mol Biol. 1995 Jul;13(1):34-44
pubmed: 7541221
Front Med (Lausanne). 2022 Mar 15;9:858339
pubmed: 35372405
Eur Respir J. 2015 May;45(5):1434-45
pubmed: 25745043
Annu Rev Pathol. 2022 Jan 24;17:515-546
pubmed: 34813355
Exp Hematol. 2018 Jul;63:22-27.e3
pubmed: 29654952
Clin Chim Acta. 2009 Jan;399(1-2):88-91
pubmed: 18835553
Thromb Haemost. 1990 Jun 28;63(3):493-8
pubmed: 2402751
J Clin Med. 2021 Apr 01;10(7):
pubmed: 33916077
Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6805-9
pubmed: 1650483
Front Pharmacol. 2022 Jan 19;12:797292
pubmed: 35126134
Am J Respir Crit Care Med. 2018 Jul 15;198(2):245-255
pubmed: 29420060
Blood. 2012 Jan 26;119(4):1064-74
pubmed: 22134166