The effect of mycophenolate mofetil on podocytes in nephrotoxic serum nephritis.

Mycophenolic Acid / administration & dosage Animals Mice Podocytes / drug effects Nephritis / drug therapy Mice, Inbred C57BL Kidney Glomerulus / chemistry Proteome / drug effects Actin Cytoskeleton / drug effects

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 08 2023
Historique:
received: 28 04 2023
accepted: 23 08 2023
medline: 31 8 2023
pubmed: 30 8 2023
entrez: 29 8 2023
Statut: epublish

Résumé

Mycophenolate mofetil (MMF) is applied in proteinuric kidney diseases, but the exact mechanism of its effect on podocytes is still unknown. Our previous in vitro experiments suggested that MMF can ameliorate podocyte damage via restoration of the Ca

Identifiants

DOI: 10.1038/s41598-023-41222-1 PMID: 37644089 PMC: PMC10465485
pubmed: 37644089
doi: 10.1038/s41598-023-41222-1
pii: 10.1038/s41598-023-41222-1
pmc: PMC10465485
doi:

Substances chimiques

Mycophenolic Acid HU9DX48N0T
Proteome 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14167

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

A Hackl (A)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany. agnes.hackl@uk-koeln.de.
CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany. agnes.hackl@uk-koeln.de.

E Nüsken (E)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.

J Voggel (J)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.

S E D Abo Zed (SED)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.
CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

J Binz-Lotter (J)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

D Unnersjö-Jess (D)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

C Müller (C)

Department of Therapeutic Drug Monitoring, Pharmacology at the Laboratory Centre, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

G Fink (G)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.

K Bohl (K)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

E Wiesner (E)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

P Diefenhardt (P)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

C Dafinger (C)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.
CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

H Chen (H)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

M Wohlfarth (M)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.

R-U Müller (RU)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Rare Kidney Diseases Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

M J Hackl (MJ)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

B Schermer (B)

CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Department 2 of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

K-D Nüsken (KD)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.

L T Weber (LT)

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Street 62, 50937, Cologne, Germany.
Center for Rare Kidney Diseases Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acide mycophénolique › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Eucaryotes › Animaux › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Cellules › Cellules épithéliales › Podocytes › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Glomérule rénal › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › The effect of mycophenolate mofetil on...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Cytosquelette d'actine › The effect of mycophenolate mofetil on...