Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
29 Aug 2023
29 Aug 2023
Historique:
received:
20
01
2023
accepted:
07
08
2023
revised:
02
08
2023
medline:
30
8
2023
pubmed:
30
8
2023
entrez:
29
8
2023
Statut:
aheadofprint
Résumé
Converging evidence suggests that schizophrenia (SZ) with primary, enduring negative symptoms (i.e., Deficit SZ (DSZ)) represents a distinct entity within the SZ spectrum while the neurobiological underpinnings remain undetermined. In the largest dataset of DSZ and Non-Deficit (NDSZ), we conducted a meta-analysis of data from 1560 individuals (168 DSZ, 373 NDSZ, 1019 Healthy Controls (HC)) and a mega-analysis of a subsampled data from 944 individuals (115 DSZ, 254 NDSZ, 575 HC) collected across 9 worldwide research centers of the ENIGMA SZ Working Group (8 in the mega-analysis), to clarify whether they differ in terms of cortical morphology. In the meta-analysis, sites computed effect sizes for differences in cortical thickness and surface area between SZ and control groups using a harmonized pipeline. In the mega-analysis, cortical values of individuals with schizophrenia and control participants were analyzed across sites using mixed-model ANCOVAs. The meta-analysis of cortical thickness showed a converging pattern of widespread thinner cortex in fronto-parietal regions of the left hemisphere in both DSZ and NDSZ, when compared to HC. However, DSZ have more pronounced thickness abnormalities than NDSZ, mostly involving the right fronto-parietal cortices. As for surface area, NDSZ showed differences in fronto-parietal-temporo-occipital cortices as compared to HC, and in temporo-occipital cortices as compared to DSZ. Although DSZ and NDSZ show widespread overlapping regions of thinner cortex as compared to HC, cortical thinning seems to better typify DSZ, being more extensive and bilateral, while surface area alterations are more evident in NDSZ. Our findings demonstrate for the first time that DSZ and NDSZ are characterized by different neuroimaging phenotypes, supporting a nosological distinction between DSZ and NDSZ and point toward the separate disease hypothesis.
Identifiants
pubmed: 37644174
doi: 10.1038/s41380-023-02221-w
pii: 10.1038/s41380-023-02221-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : RC 23
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : RC 23
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : RF-2019-12370182
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : RC 23
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : RC 23
Organisme : U.S. Department of Veterans Affairs (Department of Veterans Affairs)
ID : 1IK6CX002519
Organisme : Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)
ID : NIH R01 MH076989
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH-092443, MH-094268, MH-105660, and MH-107730
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH116147, R01MH121246, and R01MH129742
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH117601
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH116147, R01MH121246, and R01MH129742
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R21MH097196
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH121246
Organisme : National Healthcare Group (NHG)
ID : SIG/05004; SIG/05028
Organisme : Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic)
ID : NU21-08-00432; NU20-04-00393
Organisme : Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic)
ID : NU21-08-00432; NU20-04-00393
Informations de copyright
© 2023. The Author(s).
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