The microtubule signature in cardiac disease: etiology, disease stage, and age dependency.
Cardiac
Cardiac remodeling
Cardiomyopathy
Desmin
Dilated
Hypertrophic
Microtubules
Myocytes
Ventricular
Journal
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
ISSN: 1432-136X
Titre abrégé: J Comp Physiol B
Pays: Germany
ID NLM: 8413200
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
06
12
2022
accepted:
05
08
2023
revised:
03
08
2023
pubmed:
30
8
2023
medline:
30
8
2023
entrez:
29
8
2023
Statut:
ppublish
Résumé
Employing animal models to study heart failure (HF) has become indispensable to discover and test novel therapies, but their translatability remains challenging. Although cytoskeletal alterations are linked to HF, the tubulin signature of common experimental models has been incompletely defined. Here, we assessed the tubulin signature in a large set of human cardiac samples and myocardium of animal models with cardiac remodeling caused by pressure overload, myocardial infarction or a gene defect. We studied levels of total, acetylated, and detyrosinated α-tubulin and desmin in cardiac tissue from hypertrophic (HCM) and dilated cardiomyopathy (DCM) patients with an idiopathic (n = 7), ischemic (n = 7) or genetic origin (n = 59), and in a pressure-overload concentric hypertrophic pig model (n = 32), pigs with a myocardial infarction (n = 28), mature pigs (n = 6), and mice (n = 15) carrying the HCM-associated MYBPC3
Identifiants
pubmed: 37644284
doi: 10.1007/s00360-023-01509-1
pii: 10.1007/s00360-023-01509-1
pmc: PMC10533615
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
581-595Subventions
Organisme : Fondation Leducq
ID : 673168
Organisme : ICIN Netherlands Heart Institute
ID : CVON2014-40 DOSIS
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : NWO-ZonMW
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 91818602 VICI
Informations de copyright
© 2023. The Author(s).
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