A unique cytotoxic CD4
CD4‐CTLs
COVID‐19
SARS‐CoV‐2
T cells
spectral cytometry
Journal
Clinical & translational immunology
ISSN: 2050-0068
Titre abrégé: Clin Transl Immunology
Pays: Australia
ID NLM: 101638268
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
03
2023
revised:
04
06
2023
revised:
09
08
2023
accepted:
11
08
2023
medline:
30
8
2023
pubmed:
30
8
2023
entrez:
30
8
2023
Statut:
epublish
Résumé
SARS-CoV-2 infection causes a spectrum of clinical disease presentation, ranging from asymptomatic to fatal. While neutralising antibody (NAb) responses correlate with protection against symptomatic and severe infection, the contribution of the T-cell response to disease resolution or progression is still unclear. As newly emerging variants of concern have the capacity to partially escape NAb responses, defining the contribution of individual T-cell subsets to disease outcome is imperative to inform the development of next-generation COVID-19 vaccines. Immunophenotyping of T-cell responses in unvaccinated individuals was performed, representing the full spectrum of COVID-19 clinical presentation. Computational and manual analyses were used to identify T-cell populations associated with distinct disease states. Critical SARS-CoV-2 infection was characterised by an increase in activated and cytotoxic CD4 Highly activated and cytotoxic CD4
Identifiants
pubmed: 37645435
doi: 10.1002/cti2.1463
pii: CTI21463
pmc: PMC10461786
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1463Informations de copyright
© 2023 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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