Tumor cell p38 inhibition to overcome immunotherapy resistance.

MAPK clinical trial human specimens immune exclusion immunotherapy non-T cell-inflamed tumors p38 resistance response tumor microenvironment tumor-intrinsic

Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
19 Aug 2023
Historique:
pubmed: 30 8 2023
medline: 30 8 2023
entrez: 30 8 2023
Statut: epublish

Résumé

Patients with tumors that do not respond to immune-checkpoint inhibition often harbor a non-T cell-inflamed tumor microenvironment, characterized by the absence of IFN-γ-associated CD8

Identifiants

DOI: 10.21203/rs.3.rs-3183496/v1 PMID: 37645831 PMC: PMC10462255
pubmed: 37645831
doi: 10.21203/rs.3.rs-3183496/v1
pmc: PMC10462255
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : T32 CA082084
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA254865
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186690
Pays : United States
Organisme : NIH HHS
ID : S10 OD028483
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097190
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE031729
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE032337
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028105
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028061
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211241
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States

Auteurs

Jason J Luke (JJ)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-1182-4908

Rebekah E Dadey (RE)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Ryan C Augustin (RC)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Sarah Newman (S)

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Krishna B Singh (KB)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Rose Doerfler (R)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Sarah Behr (S)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.

Patrice Lee (P)

Pfizer, Inc. Boulder, CO, USA.

Brian Isett (B)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Cancer Bioinformatics Core, UPMC, Pittsburgh, PA, USA.

Christopher Deitrick (C)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Cancer Bioinformatics Core, UPMC, Pittsburgh, PA, USA.

Aofei Li (A)

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Marion Joy (M)

Translational Pathology Imaging Laboratory, UPMC, Pittsburgh, PA, USA.

Carly Reeder (C)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Katelyn Smith (K)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.

Julie Urban (J)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.

Lorenzo Sellitto (L)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.

Mark Jelinek (M)

Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Biostatistics Core, UPMC, Pittsburgh, PA, USA.

Susan M Christner (SM)

Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

Jan H Beumer (JH)

Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh, PA, USA.

Liza C Villaruz (LC)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Aditi Kulkarni (A)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Diwakar Davar (D)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-7846-8055

Andrew S Poklepovic (AS)

Departments of Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Departments of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Yana Najjar (Y)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Dan P Zandberg (DP)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.

Adam C Soloff (AC)

Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Tullia C Bruno (TC)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-6433-0207

Lazar Vujanović (L)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0003-1729-8619

Heath D Skinner (HD)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA.

Robert L Ferris (RL)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Riyue Bao (R)

Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-6105-1704

Classifications MeSH