Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4

Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
22 Aug 2023
Historique:
pubmed: 30 8 2023
medline: 30 8 2023
entrez: 30 8 2023
Statut: epublish

Résumé

HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We observed that approximately 1-5% of CD4

Identifiants

DOI: 10.21203/rs.3.rs-2924123/v1 PMID: 37645926 PMC: PMC10462243
pubmed: 37645926
doi: 10.21203/rs.3.rs-2924123/v1
pmc: PMC10462243
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

Financial and non-financial competing interest The authors declare no competing interests.

Auteurs

Jung-Eun Park (JE)

Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
These authors contributed equally to this work.
ORCID: 0000-0001-9929-830X

Tae-Sung Kim (TS)

Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
These authors contributed equally to this work.
ORCID: 0000-0001-8592-3848

Yan Zeng (Y)

Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Christina M Monnie (CM)

Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, RM 1055, 3501 Fifth Ave., Pittsburgh, PA, 15260, USA.

Muhammad S Alam (MS)

Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Ming Zhou (M)

Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21702, USA.
ORCID: 0000-0002-7460-550X

Melissa Mikolaj (M)

Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Frank Maldarelli (F)

HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.
ORCID: 0000-0002-3062-5250

Kedar Narayan (K)

Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
ORCID: 0000-0001-7982-6494

Jinwoo Ahn (J)

Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, RM 1055, 3501 Fifth Ave., Pittsburgh, PA, 15260, USA.
ORCID: 0000-0003-4339-0515

Jonathan D Ashwell (JD)

Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
ORCID: 0000-0002-7386-8738

Klaus Strebel (K)

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.

Kyung S Lee (KS)

Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
ORCID: 0000-0001-8326-7162

Classifications MeSH