The microenvironment dictates glycocalyx construction and immune surveillance.

ECM Mechanopharmacology bleb glycoform glycome glycosylation immune surveillance lectin array lectin microarray mechano-metabolic metabolism microenvironment sialic acid

Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
16 Aug 2023
Historique:
pubmed: 30 8 2023
medline: 30 8 2023
entrez: 30 8 2023
Statut: epublish

Résumé

Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are built with

Identifiants

DOI: 10.21203/rs.3.rs-3164966/v1 PMID: 37645943 PMC: PMC10462183
pubmed: 37645943
doi: 10.21203/rs.3.rs-3164966/v1
pmc: PMC10462183
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : R01 CA222508
Pays : United States
Organisme : NIH HHS
ID : S10 OD028611
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA108462
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA192914
Pays : United States
Organisme : NIGMS NIH HHS
ID : K99 GM147304
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA242447
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227942
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA236156
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA253744
Pays : United States

Déclaration de conflit d'intérêts

Competing Interests J.R.C. is an inventor on an issued patent for Human Plasma-Like Medium (HPLM) assigned to the Whitehead Institute (Application number: PCT/US2017/061377. Patent number: 11453858. Issue date: 09/27/2022)

Auteurs

Kevin M Tharp (KM)

Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

Sangwoo Park (S)

Field of Biophysics, Cornell University, Ithaca, NY 14850, USA.

Greg A Timblin (GA)

Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

Alicia L Richards (AL)

Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA.

Jordan A Berg (JA)

Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.

Nicholas M Twells (NM)

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

Nicholas M Riley (NM)

Department of Chemistry, Sarafan ChEM-H, Stanford University, Stanford, CA, USA.

Egan L Peltan (EL)

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford CA USA 94305.
Sarafan ChEM-H, Stanford University, Stanford, CA USA 94305.

D Judy Shon (DJ)

Department of Chemistry, Sarafan ChEM-H, Stanford University, Stanford, CA, USA.

Erica Stevenson (E)

Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA.

Kimberly Tsui (K)

Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94597, USA.

Francesco Palomba (F)

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California, CA 92697, USA.

Austin E Y T Lefebvre (AEYT)

Calico Life Sciences, South San Francisco, CA, USA.

Ross W Soens (RW)

Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

Nadia M E Ayad (NME)

Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

Johanna Ten Hoeve-Scott (JT)

UCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.

Kevin Healy (K)

Department of Chemical and Systems Biology, Sarafan ChEM-H and Howard Hughes Medical Institute, Stanford University, Stanford, CA USA 94305.
ORCID: 0000-0002-8524-3671

Michelle Digman (M)

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California, CA 92697, USA.
ORCID: 0000-0003-4611-7100

Andrew Dillin (A)

Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94597, USA.

Carolyn R Bertozzi (CR)

Department of Chemical and Systems Biology, Sarafan ChEM-H and Howard Hughes Medical Institute, Stanford University, Stanford, CA USA 94305.

Danielle L Swaney (DL)

Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA.

Lara K Mahal (LK)

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

Jason R Cantor (JR)

Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry and Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

Matthew J Paszek (MJ)

Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA.

Valerie M Weaver (VM)

Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Department of Bioengineering and Therapeutic Sciences, Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA.
ORCID: 0000-0003-4786-6752

Classifications MeSH