Insights into RAG evolution from the identification of "missing link" family A
DDE transposase
Recombination activating gene (RAG)
V(D)J recombination
evolution
transposition
transposon molecular domestication
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
20 Aug 2023
20 Aug 2023
Historique:
pubmed:
30
8
2023
medline:
30
8
2023
entrez:
30
8
2023
Statut:
epublish
Résumé
A series of "molecular domestication" events are thought to have converted an invertebrate RAG-like (RAGL) transposase into the RAG1-RAG2 (RAG) recombinase, a critical enzyme for adaptive immunity in jawed vertebrates. The timing and order of these events is not well understood, in part because of a dearth of information regarding the invertebrate
Identifiants
pubmed: 37645967
doi: 10.1101/2023.08.20.553239
pmc: PMC10462144
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI137079
Pays : United States
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
DECLARATION OF INTERESTS The authors declare no competing interests.