Mechanism of substrate binding and transport in BASS transporters.
Membrane transporter
bile acid transporter
crystal structure
elevator mechanism
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
16 Aug 2023
16 Aug 2023
Historique:
pubmed:
30
8
2023
medline:
30
8
2023
entrez:
30
8
2023
Statut:
epublish
Résumé
The Bile Acid Sodium Symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants. These transporters, many of which are sodium-coupled, have been shown to use an elevator mechanism of transport, but exactly how substrate binding is coupled to sodium ion binding and transport is not clear. Here we solve the crystal structure at 2.3 Å of a transporter from
Identifiants
pubmed: 37645971
doi: 10.1101/2023.06.02.543391
pmc: PMC10461908
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM118772
Pays : United States
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
Competing interests: Authors declare no competing interests.