Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage.

Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severity of these complications in maternal-fetal health. Here, we investigated the genetic variation underlying aspects of pregnancy-associated bleeding and identified five loci associated with PPH through a meta-analysis of 21,512 cases and 259,500 controls. Functional annotation analysis indicated candidate genes,

Déclaration de conflit d'intérêts

Competing interests H.S.N. obtained speaker fees from Ferring Pharmaceuticals, Merck A/S, AstraZeneca and Cook Medical. S.B. has ownership in Hoba Therapeutics Aps, Novo Nordisk A/S, Lundbeck A/S, ALK Abello and managing board memberships in Proscion A/S and Intomics A/S. All authors affiliated with deCODE genetics are employees of deCODE genetics, a subsidiary of Amgen.