Engineering a Cortisol Sensing Enteric Probiotic.
5-HT
5-alpha-tetrahydrocortisol
Clostridium scindens
EcN
Escherichia coli Nissle 1917
adrenal
bacterial sensor
bacterial targeted gene integration
biosensor
chronic stress
cortisol
engineered probiotic
glucocorticoid
gut brain axis
lysR transcription factor
probiotics
sense and respond circuit
serotonin
smart probiotic
tryptamine
tryptophan
tryptophan decarboxylase
Journal
ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670
Informations de publication
Date de publication:
11 09 2023
11 09 2023
Historique:
medline:
12
9
2023
pubmed:
30
8
2023
entrez:
30
8
2023
Statut:
ppublish
Résumé
Chronic stress can lead to prolonged adrenal gland secretion of cortisol, resulting in human ailments such as anxiety, post-traumatic stress disorder, metabolic syndrome, diabetes, immunosuppression, and cardiomyopathy. Real time monitoring of chronic increases in cortisol and intervening therapies to minimize the physiological effects of stress would be beneficial to prevent these endocrine related illnesses. Gut microbiota have shown the ability to secrete, respond, and even regulate endocrine hormones. One such microbe,
Identifiants
pubmed: 37647169
doi: 10.1021/acsbiomaterials.2c01300
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM