A blood-based marker of mitochondrial DNA damage in Parkinson's disease.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
30 08 2023
30 08 2023
Historique:
medline:
1
9
2023
pubmed:
30
8
2023
entrez:
30
8
2023
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and neuroprotective or disease-modifying interventions remain elusive. High-throughput markers aimed at stratifying patients on the basis of shared etiology are required to ensure the success of disease-modifying therapies in clinical trials. Mitochondrial dysfunction plays a prominent role in the pathogenesis of PD. Previously, we found brain region-specific accumulation of mitochondrial DNA (mtDNA) damage in PD neuronal culture and animal models, as well as in human PD postmortem brain tissue. To investigate mtDNA damage as a potential blood-based marker for PD, we describe herein a PCR-based assay (Mito DNA
Identifiants
pubmed: 37647388
doi: 10.1126/scitranslmed.abo1557
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabo1557Subventions
Organisme : NINDS NIH HHS
ID : F31 NS089111
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG076663
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024827
Pays : United States
Organisme : Medical Research Council
ID : MCUU12016/2
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : SCAF/18/01
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS064934
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005133
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS119528
Pays : United States