Elevated interleukin-10 levels in patients with ocular toxoplasmosis.
Interleukin-10
Toxoplasma gondii
cytokines
intraocular lymphoma
ocular toxoplasmosis
uveitis
Journal
Parasites, hosts and diseases
ISSN: 2982-6799
Titre abrégé: Parasites Hosts Dis
Pays: Korea (South)
ID NLM: 9918574074806676
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
26
01
2023
accepted:
18
06
2023
medline:
1
9
2023
pubmed:
31
8
2023
entrez:
30
8
2023
Statut:
ppublish
Résumé
In elderly patients, ocular toxoplasmosis is one of the most common etiologies of uveitis, which should be differentially diagnosed from ocular lymphoma, another common pathology of uveitis in older adults. The high level of interleukin (IL)-10 and an IL-10/IL-6 ratio higher than 1 (>1.0) are helpful parameters to diagnose ocular lymphoma. In this study, we used aqueous humor samples to detect 4 cases of ocular toxoplasmosis in patients with high levels of IL-10 and an IL-10/IL-6 ratio higher than 1. Our results show that ocular toxoplasmosis may be associated with increased cytokine levels in aqueous humor.
Identifiants
pubmed: 37648237
pii: PHD.22172
doi: 10.3347/PHD.22172
pmc: PMC10471474
doi:
Substances chimiques
Interleukin-10
130068-27-8
Interleukin-6
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
310-316Subventions
Organisme : National Research Foundation of Korea
ID : 2020R1F1A1074898
Références
Ophthalmology. 1999 Dec;106(12):2291-5
pubmed: 10599659
J Neuroimmunol. 2005 Aug;165(1-2):63-74
pubmed: 16005735
Clin Exp Immunol. 1999 Jun;116(3):410-4
pubmed: 10361227
Parasitol Res. 2007 Jan;100(2):191-203
pubmed: 17024357
Curr Opin Oncol. 2001 May;13(3):137-42
pubmed: 11307054
Graefes Arch Clin Exp Ophthalmol. 2004 Nov;242(11):901-13
pubmed: 15565454
J Clin Microbiol. 2000 Mar;38(3):996-1001
pubmed: 10698986
Parasite Immunol. 2004 Feb;26(2):75-82
pubmed: 15225294
Parasite Immunol. 2006 Nov;28(11):549-65
pubmed: 17042927
Curr Opin Ophthalmol. 2006 Dec;17(6):557-61
pubmed: 17065925
Ophthalmology. 1992 Jul;99(7):1153-60; discussion 1160-1
pubmed: 1495797
Curr Opin Ophthalmol. 2002 Dec;13(6):411-8
pubmed: 12441846
Eye (Lond). 2000 Oct;14 Pt 5:706-10
pubmed: 11116689
Epidemiol Infect. 1999 Oct;123(2):283-9
pubmed: 10579449
Am J Ophthalmol. 1996 Jan;121(1):35-46
pubmed: 8554079
Ophthalmology. 2001 Mar;108(3):426-7
pubmed: 11237883
Ophthalmology. 2007 Jul;114(7):1372-7
pubmed: 17324466
Ocul Immunol Inflamm. 2011 Oct;19(5):297-306
pubmed: 21970661
Retina. 1992;12(3 Suppl):S64-70
pubmed: 1455086