A pentameric TRPV3 channel with a dilated pore.

Anhydrides / chemistry Data Analysis Diffusion Protein Subunits / chemistry TRPV Cation Channels / chemistry Microscopy, Atomic Force Molecular Targeted Therapy Cryoelectron Microscopy Protein Structure, Quaternary / drug effects Protein Multimerization / drug effects

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 18 01 2023
accepted: 21 07 2023
medline: 8 9 2023
pubmed: 31 8 2023
entrez: 30 8 2023
Statut: ppublish

Résumé

Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily that control diverse physiological functions, and therefore are attractive drug targets

Identifiants

DOI: 10.1038/s41586-023-06470-1 PMID: 37648856 PMC: PMC10584365
pubmed: 37648856
doi: 10.1038/s41586-023-06470-1
pii: 10.1038/s41586-023-06470-1
pmc: PMC10584365
mid: NIHMS1935826
doi:

Substances chimiques

Anhydrides 0
Protein Subunits 0
diphenylborate 83075-94-9
TRPV Cation Channels 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

206-214

Subventions

Organisme : NCCIH NIH HHS
ID : DP1 AT010874
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099341
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Shifra Lansky (S)

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-2037-7388

John Michael Betancourt (JM)

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Neuroscience Graduate Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.

Jingying Zhang (J)

Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.
Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA.
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Yining Jiang (Y)

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Biochemistry and Structural Biology, Cell and Developmental Biology, and Molecular Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-7624-4488

Elizabeth D Kim (ED)

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.

Navid Paknejad (N)

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medical College, New York, NY, USA.
ORCID: 0000-0001-8914-7604

Crina M Nimigean (CM)

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-6254-4447

Peng Yuan (P)

Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.
Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA.
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Simon Scheuring (S)

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA. sis2019@med.cornell.edu.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. sis2019@med.cornell.edu.
ORCID: 0000-0003-3534-069X

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Anhydrides › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Disciplines des sciences naturelles › Mathématiques › Analyse de données › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Phénomènes chimiques › Diffusion › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sous-unités de protéines › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Techniques d'investigation › Microscopie à sonde à balayage › Microscopie à force atomique › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure quaternaire des protéines › A pentameric TRPV3 channel with a dilated pore.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › A pentameric TRPV3 channel with a dilated pore.