Cytomorphologic panorama of giant cell tumour of tendon sheath.
cytomorphology
fine needle aspiration cytology
giant cell tumour of tendon sheath
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
18
07
2023
accepted:
17
08
2023
medline:
2
11
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
ppublish
Résumé
Giant Cell Tumour of Tendon Sheath (GCTTS) is a slow growing benign soft tissue tumour arising from synovium of tendon sheath or joint. These tumours occur more frequently in upper limbs, especially hands. In the present study, we aimed to evaluate the cytomorphological spectrum of GCTTS. This retrospective study includes a total of 56 cases of GCTTS diagnosed over a period of 8 years. The clinical and radiological details of these cases were retrieved from the cytopathology records and detailed cytomorphological features were studied and analysed. Histopathological correlation was done in 16/56 cases, where follow-up was available. The mean age of patients at the time of presentation was 32 years and were predominantly females (68%). The most common site of GCTTS was fingers (76%), followed by foot, wrist and toes. The most consistent finding on cytology was stromal cells (100%) of polygonal, spindle and plasmacytoid morphology with interspersed multinucleated osteoclastic giant cells (100%), followed by binucleated stromal cells (75%), xanthoma cells (61%) and hemosiderin laden macrophages (52%). Presence of proteinaceous fluid background was also observed in 50% of the cases. GCTTS can be diagnosed with certainty on FNAC based on characteristic cytomorphological features in an appropriate clinical and radiological setting. FNAC plays a pivotal role in diagnosing GCTTS and differentiating it from other giant cell rich lesions, thus obviating the need of tissue biopsy for diagnosis, which in turn helps the clinician in timely and adequate management of the patient.
Sections du résumé
BACKGROUND
BACKGROUND
Giant Cell Tumour of Tendon Sheath (GCTTS) is a slow growing benign soft tissue tumour arising from synovium of tendon sheath or joint. These tumours occur more frequently in upper limbs, especially hands. In the present study, we aimed to evaluate the cytomorphological spectrum of GCTTS.
METHODS
METHODS
This retrospective study includes a total of 56 cases of GCTTS diagnosed over a period of 8 years. The clinical and radiological details of these cases were retrieved from the cytopathology records and detailed cytomorphological features were studied and analysed. Histopathological correlation was done in 16/56 cases, where follow-up was available.
RESULTS
RESULTS
The mean age of patients at the time of presentation was 32 years and were predominantly females (68%). The most common site of GCTTS was fingers (76%), followed by foot, wrist and toes. The most consistent finding on cytology was stromal cells (100%) of polygonal, spindle and plasmacytoid morphology with interspersed multinucleated osteoclastic giant cells (100%), followed by binucleated stromal cells (75%), xanthoma cells (61%) and hemosiderin laden macrophages (52%). Presence of proteinaceous fluid background was also observed in 50% of the cases.
CONCLUSION
CONCLUSIONS
GCTTS can be diagnosed with certainty on FNAC based on characteristic cytomorphological features in an appropriate clinical and radiological setting. FNAC plays a pivotal role in diagnosing GCTTS and differentiating it from other giant cell rich lesions, thus obviating the need of tissue biopsy for diagnosis, which in turn helps the clinician in timely and adequate management of the patient.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
772-778Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
Batra VV, Jain S, Singh DK, Kumar N. Cytomorphologic spectrum of giant cell tumor of tendon sheath. Acta Cytol. 2008;52:152-158.
Weiss SW, Goldblum JR. Benign tumours and tumour-like lesions of synovial tissue. In: Weiss SW, Goldblum JR, eds. Enzinger and Weiss's Soft Tissue Tumours. 4th ed. Mosby; 2001:1038-1054.
Jain S, Nanda S, Shastri M, Nanda A, Garg V. Fine needle aspiration cytology of giant cell tumour of tendon sheath. J Clin Diagn Res. 2022;16(3):EC05-EC07.
Iyer VK, Kapila K, Verma K. Fine needle aspiration cytology of giant cell tumor of tendon sheath. Diagn Cytopathol. 2003;29:105-110.
Ho CY, Maleki Z. Giant cell tumor of tendon sheath: cytomorphologic and radiologic findings in 41 patients. Diagn Cytopathol. 2012;40(S2):E94-E98.
Kumar R, Bharani V, Gupta N, et al. Giant cell tumour of tendon sheath: a 10-year study from a tertiary care centre. Cytopathology. 2018;29(3):288-293.
Gupta K, Dey P, Goldsmith R, Vasishta RK. Comparison of cytologic features of giant-cell tumor and giant-cell tumor of tendon sheath. Diagn Cytopathol. 2004;30:14-18.
Dhadwadkar A, Vimal S, Shetty A, Vishwanathan V. Giant cell tumor of the tendon sheath: a cytomorphological study of 21 cases. Eur J Pharm Med Res. 2017;4(6):576-580.
Tamer TM. Hyaluronan and synovial joint: function, distribution and healing. Interdiscip Toxicol. 2013;6(3):111-125.
Krishnappa A, Shobha SN, Shankar SV, Aradhya S. Fine needle aspiration cytology of chondroblastoma: a report of two cases with brief review of pitfalls. J Cytol. 2016;33:40-42.
Wakely PE Jr. Giant cell tumor of soft tissue: FNA cytopathology of 4 cases, review of the literature, and comparison with giant cell tumor of bone. Cancer Cytopathol. 2022;130(2):120-127.
Creager AJ, Madden CR, Bergman S, Geisinger KR. Aneurysmal bone cyst: fine-needle aspiration findings in 23 patients with clinical and radiologic correlation. Am J Clin Pathol. 2007;128(5):740-745.
Handa U, Mundi I, Mohan H, Garg SK. Cytological diagnosis of small cell osteosarcoma of the bone. J Cytol. 2015;32(2):136-138.