Depleting transforming growth factor beta receptor 2 signalling in the cartilage of
Articular cartilage
Histology
Integrins
Mouse
Osteoarthritis
Transforming growth factor-beta type II receptor
Journal
Osteoarthritis and cartilage open
ISSN: 2665-9131
Titre abrégé: Osteoarthr Cartil Open
Pays: England
ID NLM: 101767068
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
03
08
2023
accepted:
09
08
2023
medline:
31
8
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
epublish
Résumé
Integrin α1β1 protects against osteoarthritis (OA) when it is upregulated in the superficial zone of cartilage in the early stages of disease. However, the mechanism behind this protection is unknown. Integrin α1β1 moderates transforming growth factor β receptor II (TGFBR2) signalling, a critical regulator of chondrocyte anabolic activity. To this end, mice lacking integrin α1β1 have increased baseline activation of TGFBR2 signalling and overall fibrosis. The purpose of this study was to evaluate the interplay between integrin α1β1 and TGFBR2 in the development of spontaneous OA. We hypothesized that dampening TGFBR2 signalling in the cartilage of Behavioural and histological manifestations of spontaneous knee OA were measured at 4, 8, 12 and 16 months in mice with and without a ubiquitous Knee cartilage degeneration, collateral ligament ossification and pain responses increased with age. Intact TGFBR2 signalling drives early and worse knee OA in
Identifiants
pubmed: 37649532
doi: 10.1016/j.ocarto.2023.100399
pii: S2665-9131(23)00066-3
pmc: PMC10462827
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100399Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
None of the authors declare any conflict of interest.
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