Comparison of random urine protein/creatinine ratio with 24-hour urine protein in suspected pre-eclampsia.
24-H urine protein excretion
Pre-eclampsia
Protein-creatinine-ratio
Proteinuria
Journal
Practical laboratory medicine
ISSN: 2352-5517
Titre abrégé: Pract Lab Med
Pays: Netherlands
ID NLM: 101690848
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
07
12
2022
revised:
09
06
2023
accepted:
13
06
2023
medline:
31
8
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
epublish
Résumé
Proteinuria is one of the classical criteria for the diagnosis of pre-eclampsia. The gold standard remains the measurement of 24-h urine protein which is time consuming and prone to preanalytical errors. Random urine protein creatinine ratio (UPCR) is endorsed by clinical practice guidelines as a faster alternative. The aim of this study was to evaluate the correlation between the 24-h urine protein excretion and UPCR in the identification of proteinuria in suspected preeclamptic patients. A total of 51 women with suspected pre-eclampsia from the maternal fetal clinic of our institution were retrospectively studied. The correlation between the UPCR in random urine samples and protein excretion in the 24-h urine collection was determined by Deming Regression analysis and Pearson correlation on EP evaluator and SPSS respectively. There was a significant positive correlation between the numerical values obtained by 24-h urine protein and the UPCR (R = 0.88, P < 0.001). Concordance analysis showed 81.1% positive agreement for proteinuria between methods (>300 mg/24hr and >0.3) and 71.4% negative agreement. The clinical sensitivity and specificity of the UPCR was 74% and 69% respectively. Overall, UPCR was well correlated with 24-h urine protein and could be an effective and compliant screening tool to indicate proteinuria in preeclamptic patients.
Identifiants
pubmed: 37649542
doi: 10.1016/j.plabm.2023.e00316
pii: S2352-5517(23)00010-0
pmc: PMC10462489
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e00316Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
Lily Olayinka: None. Emily Garnett: None. Brain Burnett: None. Sridevi Devaraj: None.
Références
Obstet Gynecol Sci. 2013 Jan;56(1):8-14
pubmed: 24327974
Crit Rev Clin Lab Sci. 2020 Aug;57(5):345-364
pubmed: 32058809
Semin Nephrol. 2011 Jan;31(1):111-22
pubmed: 21266269
Iran J Kidney Dis. 2008 Jul;2(3):127-31
pubmed: 19377225
Obstet Gynecol. 2020 Jun;135(6):e237-e260
pubmed: 32443079
Circ Res. 2019 Mar 29;124(7):1094-1112
pubmed: 30920918
J Obstet Gynaecol Can. 2014 Apr;36(4):303-308
pubmed: 24798667
Pregnancy Hypertens. 2021 Aug;25:196-203
pubmed: 34237632
Am J Obstet Gynecol. 2003 Sep;189(3):848-52
pubmed: 14526328
Clin Chem. 1998 Mar;44(3):674-5
pubmed: 9510883
Pregnancy Hypertens. 2014 Jan;4(1):87-90
pubmed: 26104260
Eur J Obstet Gynecol Reprod Biol. 2013 Oct;170(2):368-71
pubmed: 23928475
Nefrologia. 2012 Jul 17;32(4):494-501
pubmed: 22806284
Hypertension. 2018 Jul;72(1):24-43
pubmed: 29899139
Balkan Med J. 2015 Jan;32(1):51-5
pubmed: 25759772