The Important Role of Interleukin-2 in COVID-19.
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
01
2023
revised:
04
06
2023
accepted:
13
07
2023
medline:
1
9
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
epublish
Résumé
There is controversial literature about the effects of the interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify the potential in the role of the IL-2 family in COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, and Web of Science. The search deadline was up to December 2022. We applied no time limits for the searching strategy. After retrieving articles from the databases, the authors summarized the data into two data extraction tables. The first data extraction table described the changes in the IL-2 cytokine family in COVID-19 and the second table described the therapeutic interventions targeting IL-2 family cytokines. The results of the literature on the role of the IL-2 cytokine family do not show a singular rule. IL-2 cytokine family can change during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some studies suggest that IL-2 cytokine family rise during the infection and cause severe inflammatory response and cytokine storm. These cytokines are shown to be increased in immunocompromised patients and worsen their prognosis. In individuals without underlying disease, the upregulation of the IL-2 family shows the clinical outcome of the disease and rises with disease severity. However, some other studies show that these cytokines do not significantly change. IL-2 cytokine family is mostly upregulated in healthy individuals who had vaccination, but immunocompromised patients did not show significant changes after a single dose of vaccines, which shows that these patients need booster doses for efficient immunity. IL-2 cytokine family can also be used as immunotherapy agents in COVID-19.
Identifiants
pubmed: 37649897
doi: 10.1155/2023/7097329
pmc: PMC10465260
doi:
Substances chimiques
Cytokines
0
Interleukin-2
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7097329Informations de copyright
Copyright © 2023 Leila Ghanbari Naeini et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Ital J Pediatr. 2021 Feb 15;47(1):32
pubmed: 33588905
J Pers Med. 2021 Dec 08;11(12):
pubmed: 34945800
Front Immunol. 2022 Aug 05;13:926318
pubmed: 35990701
Postgrad Med. 2021 Jun;133(5):489-507
pubmed: 33245005
Nat Commun. 2023 Jul 10;14(1):4060
pubmed: 37429848
J Immunol. 2001 Aug 1;167(3):1550-7
pubmed: 11466376
Physiol Res. 2020 Jul 16;69(3):379-388
pubmed: 32469225
Front Immunol. 2022 Aug 15;13:943563
pubmed: 36045688
Int J Mol Sci. 2021 May 18;22(10):
pubmed: 34069940
Front Immunol. 2022 Aug 25;13:919402
pubmed: 36091037
Allergol Immunopathol (Madr). 2022 Jan 01;50(1):37-50
pubmed: 34873895
Allergol Immunopathol (Madr). 2023 Jan 01;51(1):1-8
pubmed: 36617815
Curr Mol Pharmacol. 2022;15(4):683-692
pubmed: 34477540
Sci Rep. 2020 Oct 29;10(1):18689
pubmed: 33122784
J Immunol. 2012 Nov 1;189(9):4213-9
pubmed: 23087426
Cell Rep. 2021 Aug 10;36(6):109504
pubmed: 34352226
Microorganisms. 2021 Jun 13;9(6):
pubmed: 34199203
J Pers Med. 2022 Mar 03;12(3):
pubmed: 35330391
Nat Med. 2022 Jan;28(1):39-50
pubmed: 35064248
OMICS. 2021 Jan;25(1):13-22
pubmed: 32857671
Nat Commun. 2022 May 11;13(1):2576
pubmed: 35546150
Trends Immunol. 2021 Jan;42(1):3-5
pubmed: 33214057
Oncotarget. 2016 Sep 13;7(37):60723-60735
pubmed: 27494872
Molecules. 2021 Jun 25;26(13):
pubmed: 34202374
J Immunol. 2009 Dec 1;183(11):7006-13
pubmed: 19915054
Clin Nutr ESPEN. 2022 Feb;47:414-417
pubmed: 35063236
JAMA Netw Open. 2020 Jul 1;3(7):e2016485
pubmed: 32697322
Clin Exp Immunol. 2003 May;132(2):289-96
pubmed: 12699419
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:1076029621993573
pubmed: 33571009
Int Rev Immunol. 1998;16(3-4):345-64
pubmed: 9505195
Allergol Immunopathol (Madr). 2022 Sep 01;50(5):7-15
pubmed: 36086958
Oncogene. 1999 Nov 22;18(49):6853-66
pubmed: 10602461
J Immunol. 1992 Jul 1;149(1):83-91
pubmed: 1607664
Curr Opin Microbiol. 2014 Aug;20:69-75
pubmed: 24908561
Nat Rev Immunol. 2020 Oct;20(10):581-582
pubmed: 32839569
Inflammopharmacology. 2022 Jun;30(3):811-820
pubmed: 35471628
Avicenna J Med Biotechnol. 2023 Apr-Jun;15(2):118-123
pubmed: 37034895
Pediatr Rheumatol Online J. 2022 Aug 13;20(1):64
pubmed: 35964130
Diagnostics (Basel). 2022 Aug 24;12(9):
pubmed: 36140453
PLoS One. 2021 Apr 29;16(4):e0250330
pubmed: 33914789
Biochemistry. 2002 Jul 9;41(27):8725-31
pubmed: 12093291
J Med Virol. 2021 Jan;93(1):250-256
pubmed: 32592501
Front Immunol. 2022 Aug 16;13:954985
pubmed: 36052094
Cytokine. 2012 Sep;59(3):467-78
pubmed: 22704694
Inflammopharmacology. 2022 Aug;30(4):1189-1205
pubmed: 35562628
Front Immunol. 2021 Jan 29;12:626235
pubmed: 33584733
Front Immunol. 2022 Aug 01;13:966098
pubmed: 35979361
Science. 1993 Jul 2;261(5117):93-5
pubmed: 7686307
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
pubmed: 11016959
Eur Cytokine Netw. 2020 Sep 1;31(3):81-93
pubmed: 33361013
Exp Neurobiol. 2022 Aug 31;31(4):270-276
pubmed: 36050226
Oncogene. 2019 Nov;38(48):7357-7365
pubmed: 31417180
Nature. 2000 Nov 2;408(6808):57-63
pubmed: 11081504
BMJ. 2022 Mar 2;376:e068632
pubmed: 35236664
Annu Rev Immunol. 2006;24:657-79
pubmed: 16551262
J Infect Public Health. 2022 Oct;15(10):1072-1075
pubmed: 36088825
Int J Mol Sci. 2021 Aug 18;22(16):
pubmed: 34445610
Cell Death Dis. 2020 Jun 8;11(6):429
pubmed: 32513989
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Clin Exp Immunol. 2020 Jul;201(1):76-84
pubmed: 32365221
Curr Opin Immunol. 2011 Oct;23(5):598-604
pubmed: 21889323
Science. 2005 Nov 18;310(5751):1159-63
pubmed: 16293754
Sci Immunol. 2022 Jan 07;7(67):eabm5505
pubmed: 34995097
Allergol Immunopathol (Madr). 2021 Mar 01;49(2):191-207
pubmed: 33641309
Front Immunol. 2021 Nov 11;12:749291
pubmed: 34867978
Trends Immunol. 2015 Dec;36(12):763-777
pubmed: 26572555
J Infect Dis. 2021 Apr 8;223(7):1145-1149
pubmed: 33411935
Int J Med Sci. 2021 Jan 21;18(6):1356-1362
pubmed: 33628091
Inflamm Res. 2022 Aug;71(7-8):923-947
pubmed: 35751653
Biomed Res Int. 2022 Apr 30;2022:2755246
pubmed: 35540724
J Leukoc Biol. 2002 Nov;72(5):856-63
pubmed: 12429707
PeerJ. 2020 Nov 02;8:e10322
pubmed: 33194450
Nat Immunol. 2019 Dec;20(12):1584-1593
pubmed: 31745336
Front Immunol. 2016 Oct 06;7:409
pubmed: 27766098
J Virol. 2011 Jan;85(2):733-41
pubmed: 21047960
Science. 2009 Jun 19;324(5934):1525-6
pubmed: 19541985
Methods Mol Biol. 2017;1585:21-35
pubmed: 28477184
Inflamm Regen. 2020 Oct 1;40:37
pubmed: 33014208
Allergol Immunopathol (Madr). 2022 Sep 01;50(5):162-168
pubmed: 36086977
Inform Med Unlocked. 2020;21:100458
pubmed: 33102687
J Leukoc Biol. 2022 Jun;111(6):1287-1295
pubmed: 35075682
J Nutr. 2022 Oct 6;152(10):2218-2226
pubmed: 36084236
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
J Biol Chem. 1992 Oct 5;267(28):20371-6
pubmed: 1400355
Allergol Immunopathol (Madr). 2022 Jan 01;50(1):99-103
pubmed: 34965644
Adv Exp Med Biol. 2021;1318:911-921
pubmed: 33973219
Science. 2020 Aug 7;369(6504):643-650
pubmed: 32540902
Nat Rev Immunol. 2011 Mar;11(3):158
pubmed: 21456116
J Microsc Ultrastruct. 2020 Dec 10;8(4):141-145
pubmed: 33623736
Cytokine. 2021 Jan;137:155323
pubmed: 33045526
Vaccines (Basel). 2022 Aug 18;10(8):
pubmed: 36016235
PLoS Pathog. 2019 Aug 14;15(8):e1007989
pubmed: 31412088
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Science. 1993 Dec 17;262(5141):1877-80
pubmed: 8266077
J Infect Dis. 2020 Aug 4;222(5):746-754
pubmed: 32563194
Front Immunol. 2020 Jul 10;11:1648
pubmed: 32754159
J Allergy Clin Immunol. 2020 Jul;146(1):89-100
pubmed: 32407836
J Biol Chem. 2018 Dec 21;293(51):19771-19784
pubmed: 30352872
Int J Mol Sci. 2022 Nov 16;23(22):
pubmed: 36430621
Disaster Med Public Health Prep. 2021 Aug;15(4):e24-e25
pubmed: 33046176