Oral Isotretinoin and Its Uses in Dermatology: A Review.
acne vulgaris
dermatology
isotretinoin
rosacea
skin cancer
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2023
2023
Historique:
received:
25
06
2023
accepted:
20
08
2023
medline:
1
9
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
epublish
Résumé
In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly used off-label to treat mild-to-moderate acne, inflammatory skin conditions, genodermatoses, skin cancer, and other skin disorders. This is due to its anti-inflammatory, immunomodulatory, and antineoplastic properties. Some "off-label" use is successful, while others are ineffective. Therefore, this information is essential to clinicians for deciding on the appropriate use of isotretinoin. In this article, we aim to review the most updated evidence-based data about the use of oral isotretinoin in dermatology.
Identifiants
pubmed: 37649956
doi: 10.2147/DDDT.S427530
pii: 427530
pmc: PMC10464604
doi:
Substances chimiques
Isotretinoin
EH28UP18IF
Retinoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2573-2591Informations de copyright
© 2023 Paichitrojjana and Paichitrojjana.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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