Raman spectroscopy and U-Net deep neural network in antiresorptive drug-related osteonecrosis of the jaw.
Raman spectroscopy
SERDS
U-Net
antiresorptive drug-related osteonecrosis of the jaw
background subtraction
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
31 Aug 2023
31 Aug 2023
Historique:
revised:
30
07
2023
received:
14
07
2022
accepted:
14
08
2023
medline:
31
8
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
aheadofprint
Résumé
Application of an optical method for the identification of antiresorptive drug-related osteonecrosis of the jaw (ARONJ). We introduce shifted-excitation Raman difference spectroscopy followed by U-Net deep neural network refinement to determine bone tissue viability. The obtained results are validated through established histological methods. Discrimination of osteonecrosis from physiological tissues was evaluated at 119 distinct measurement loci in 40 surgical specimens from 28 patients. Mean Raman spectra were refined from 11,900 raw spectra, and characteristic peaks were assigned to their respective molecular origin. Then, following principal component and linear discriminant analyses, osteonecrotic lesions were distinguished from physiological tissue entities, such as viable bone, with a sensitivity, specificity, and overall accuracy of 100%. Moreover, bone mineral content, quality, maturity, and crystallinity were quantified, revealing an increased mineral-to-matrix ratio and decreased carbonate-to-phosphate ratio in ARONJ lesions compared to physiological bone. The results demonstrate feasibility with high classification accuracy in this collective. The differentiation was determined by the spectral features of the organic and mineral composition of bone. This merely optical, noninvasive technique is a promising candidate to ameliorate both the diagnosis and treatment of ARONJ in the future.
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Mildred Scheel Cancer Career Center Hamburg of the German Cancer Aid
ID : 70113304
Organisme : Wilhelm Sander-Stiftung
ID : 2017.111.1
Informations de copyright
© 2023 The Authors. Oral Diseases published by Wiley Periodicals LLC.
Références
Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, & American Association of Oral and Maxillofacial Surgeons. (2007). American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. Journal of Oral and Maxillofacial Surgery, 65(3), 369-376. https://doi.org/10.1016/j.joms.2006.11.003
Al-Ghaithi, A., Husband, J., & Al-Maskari, S. (2021). Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy: Is there potential for medical management? Sultan Qaboos University Medical Journal, 21(2), e297-e301. https://doi.org/10.18295/squmj.2021.21.02.020
Assaf, A. T., Zrnc, T. A., Riecke, B., Wikner, J., Zustin, J., Friedrich, R. E., Heiland, M., Smeets, R., & Gröbe, A. (2014). Intraoperative efficiency of fluorescence imaging by visually enhanced lesion scope (VELscope) in patients with bisphosphonate related osteonecrosis of the jaw (BRONJ). Journal of Cranio-Maxillo-Facial Surgery, 42(5), e157-e164. https://doi.org/10.1016/j.jcms.2013.07.014
Aubreville, M., Knipfer, C., Oetter, N., Jaremenko, C., Rodner, E., Denzler, J., Bohr, C., Neumann, H., Stelzle, F., & Maier, A. (2017). Automatic classification of cancerous tissue in laserendomicroscopy images of the oral cavity using deep learning. Scientific Reports, 7(1), 11979. https://doi.org/10.1038/s41598-017-12320-8
Barroso, E., Smits, R., Bakker Schut, T., ten Hove, I., Hardillo, J., Wolvius, E., Baatenburg de Jong, R. J., Koljenović, S., & Puppels, G. J. (2015). Discrimination between oral cancer and healthy tissue based on water content determined by Raman spectroscopy. Analytical Chemistry, 87(4), 2419-2426. https://doi.org/10.1021/ac504362y
Bergstra, J., Komer, B., Eliasmith, C., Yamins, D., & Cox, D. D. (2015). Hyperopt: A python library for model selection and hyperparameter optimization. Computational Science & Discovery, 8(1), 014008. https://doi.org/10.1088/1749-4699/8/1/014008
Beth-Tasdogan, N. H., Mayer, B., Hussein, H., Zolk, O., & Peter, J. U. (2022). Interventions for managing medication-related osteonecrosis of the jaw. Cochrane Database of Systematic Reviews, 7(7), CD012432. https://doi.org/10.1002/14651858.CD012432.pub3
Bigio, I. J., & Bown, S. G. (2004). Spectroscopic sensing of cancer and cancer therapy: Current status of translational research. Cancer Biology & Therapy, 3(3), 259-267. https://doi.org/10.4161/cbt.3.3.694
Buchwald, T., Niciejewski, K., Kozielski, M., Szybowicz, M., Siatkowski, M., & Krauss, H. (2012). Identifying compositional and structural changes in spongy and subchondral bone from the hip joints of patients with osteoarthritis using Raman spectroscopy. Journal of Biomedical Optics, 17(1), 017007. https://doi.org/10.1117/1.JBO.17.1.017007
Butler, H. J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N. J., Gardner, B., Martin-Hirsch, P. L., Walsh, M. J., McAinsh, M. R., Stone, N., & Martin, F. L. (2016). Using Raman spectroscopy to characterize biological materials. Nature Protocols, 11(4), 664-687. https://doi.org/10.1038/nprot.2016.036
Butscheidt, S., von Kroge, S., Stürznickel, J., Beil, F. T., Gehrke, T., Püschel, K., Amling, M., Hahn, M., & Rolvien, T. (2021). Allograft chip incorporation in acetabular reconstruction: Multiscale characterization revealing osteoconductive capacity. Journal of Bone and Joint Surgery, 103(21), 1996-2005. https://doi.org/10.2106/JBJS.20.01943
Cals, F. L. J., Bakker Schut, T. C., Caspers, P. J., Baatenburg de Jong, R. J., Koljenovic, S., & Puppels, G. J. (2018). Raman spectroscopic analysis of the molecular composition of oral cavity squamous cell carcinoma and healthy tongue tissue. Analyst, 143(17), 4090-4102. https://doi.org/10.1039/c7an02106b
Carlson, E. R., & Basile, J. D. (2009). The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. Journal of Oral and Maxillofacial Surgery, 67(5 Suppl), 85-95. https://doi.org/10.1016/j.joms.2009.01.006
Chen, X., Li, X., Xie, J., Yang, H., & Liu, A. (2022). Non-invasive discrimination of multiple myeloma using label-free serum surface-enhanced Raman scattering spectroscopy in combination with multivariate analysis. Analytica Chimica Acta, 1191, 339296. https://doi.org/10.1016/j.aca.2021.339296
Colella, G., Campisi, G., & Fusco, V. (2009). American Association of Oral and Maxillofacial Surgeons position paper: Bisphosphonate-related osteonecrosis of the Jaws-2009 update: The need to refine the BRONJ definition. Journal of Oral and Maxillofacial Surgery, 67(12), 2698-2699. https://doi.org/10.1016/j.joms.2009.07.097
Crandall, C. J., Newberry, S. J., Diamant, A., Lim, Y. W., Gellad, W. F., Booth, M. J., Motala, A., & Shekelle, P. G. (2014). Comparative effectiveness of pharmacologic treatments to prevent fractures: An updated systematic review. Annals of Internal Medicine, 161(10), 711-723. https://doi.org/10.7326/M14-0317
da Silva Martins, M. A., Ribeiro, D. G., Pereira Dos Santos, E. A., Martin, A. A., Fontes, A., & da Silva Martinho, H. (2010). Shifted-excitation Raman difference spectroscopy for in vitro and in vivo biological samples analysis. Biomedical Optics Express, 1(2), 617-626. https://doi.org/10.1364/BOE.1.000617
de Sousa Ferreira, V. C., Lopes, A. P., Alves, N. M., Sousa, F. R. N., Pereira, K. M. A., Gondim, D. V., Girão, V. C. C., Leitão, R. F. C., & Goes, P. (2021). Bisphosphonate-related osteonecrosis induced change in alveolar bone architecture in rats with participation of Wnt signaling. Clinical Oral Investigations, 25(2), 673-682. https://doi.org/10.1007/s00784-020-03551-7
Deymier, A. C., Schwartz, A. G., Lim, C., Wingender, B., Kotiya, A., Shen, H., Silva, M. J., & Thomopoulos, S. (2020). Multiscale effects of spaceflight on murine tendon and bone. Bone, 131, 115152. https://doi.org/10.1016/j.bone.2019.115152
Dochow, S., Bergner, N., Matthäus, C., Praveen, B. B., Ashok, P. C., Mazilu, M., Krafft, C., Dholakia, K., & Popp, J. (2012). Etaloning, fluorescence and ambient light suppression by modulated wavelength Raman spectroscopy. Biomedical Spectroscopy and Imaging, 1(4), 383-389. https://doi.org/10.3233/bsi-120031
Dorff, T. B., & Agarwal, N. (2018). Bone-targeted therapies to reduce skeletal morbidity in prostate cancer. Asian Journal of Andrology, 20(3), 215-220. https://doi.org/10.4103/aja.aja_12_18
Dukes, P. V., Strobbia, P., Ngo, H. T., Odion, R. A., Rocke, D., Lee, W. T., & Vo-Dinh, T. (2020). Plasmonic assay for amplification-free cancer biomarkers detection in clinical tissue samples. Analytica Chimica Acta, 1139, 111-118. https://doi.org/10.1016/j.aca.2020.09.003
Durie, B. G., Katz, M., & Crowley, J. (2005). Osteonecrosis of the jaw and bisphosphonates. New England Journal of Medicine, 353(1), 99-102; discussion 199-102. https://doi.org/10.1056/NEJM200507073530120
Evans, C. L., & Xie, X. S. (2008). Coherent anti-Stokes Raman scattering microscopy: Chemical imaging for biology and medicine. Annual Review of Analytical Chemistry, 1(1), 883-909. https://doi.org/10.1146/annurev.anchem.1.031207.112754
Fiedler, I. A. K., Casanova, M., Keplinger, T., Busse, B., & Muller, R. (2018). Effect of short-term formaldehyde fixation on Raman spectral parameters of bone quality. Journal of Biomedical Optics, 23(11), 1-6. https://doi.org/10.1117/1.JBO.23.11.116504
Gamsjaeger, S., Masic, A., Roschger, P., Kazanci, M., Dunlop, J. W., Klaushofer, K., Paschalis, E. P., & Fratzl, P. (2010). Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy. Bone, 47(2), 392-399. https://doi.org/10.1016/j.bone.2010.04.608
Gebrekidan, M. T., Erber, R., Hartmann, A., Fasching, P. A., Emons, J., Beckmann, M. W., & Braeuer, A. (2018). Breast tumor analysis using shifted-excitation Raman difference spectroscopy (SERDS). Technology in Cancer Research & Treatment, 17, 1-11. https://doi.org/10.1177/1533033818782532
Gebrekidan, M. T., Knipfer, C., & Braeuer, A. S. (2021). Refinement of spectra using a deep neural network: Fully automated removal of noise and background. Journal of Raman Spectroscopy, 52(3), 723-736. https://doi.org/10.1002/jrs.6053
Gebrekidan, M. T., Knipfer, C., Stelzle, F., Popp, J., Will, S., & Braeuer, A. (2016). A shifted-excitation Raman difference spectroscopy (SERDS) evaluation strategy for the efficient isolation of Raman spectra from extreme fluorescence interference. Journal of Raman Spectroscopy, 47(2), 198-209. https://doi.org/10.1002/jrs.4775
Guze, K., Pawluk, H. C., Short, M., Zeng, H., Lorch, J., Norris, C., & Sonis, S. (2015). Pilot study: Raman spectroscopy in differentiating premalignant and malignant oral lesions from normal mucosa and benign lesions in humans. Head and Neck, 37(4), 511-517. https://doi.org/10.1002/hed.23629
Hagino, H., Soen, S., Sugimoto, T., Endo, N., Okazaki, R., Tanaka, K., & Nakamura, T. (2019). Changes in quality of life in patients with postmenopausal osteoporosis receiving weekly bisphosphonate treatment: A 2-year multicenter study in Japan. Journal of Bone and Mineral Metabolism, 37(2), 273-281. https://doi.org/10.1007/s00774-018-0914-3
Harris, A. T., Rennie, A., Waqar-Uddin, H., Wheatley, S. R., Ghosh, S. K., Martin-Hirsch, D. P., Fisher, S. E., High, A. S., Kirkham, J., & Upile, T. (2010). Raman spectroscopy in head and neck cancer. Head & Neck Oncology, 2, 26. https://doi.org/10.1186/1758-3284-2-26
Hellstein, J. W., Adler, R. A., Edwards, B., Jacobsen, P. L., Kalmar, J. R., Koka, S., Migliorati, C. A., Ristic, H., & American Dental Association Council on Scientific Affairs Expert Panel on Antiresorptive Agents. (2011). Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: Executive summary of recommendations from the American Dental Association Council on scientific affairs. Journal of the American Dental Association, 142(11), 1243-1251. https://doi.org/10.14219/jada.archive.2011.0108
Huang, Z., McWilliams, A., Lam, S., English, J., McLean, D. I., Lui, H., & Zeng, H. (2003). Effect of formalin fixation on the near-infrared Raman spectroscopy of normal and cancerous human bronchial tissues. International Journal of Oncology, 23(3), 649-655. https://doi.org/10.3892/ijo.23.3.649
Hunt, H. B., & Donnelly, E. (2016). Bone quality assessment techniques: Geometric, compositional, and mechanical characterization from macroscale to nanoscale. Clinical Reviews in Bone and Mineral Metabolism, 14(3), 133-149. https://doi.org/10.1007/s12018-016-9222-4
Ishimura, E., Zhu, W., Marin, E., Honma, T., Sugano, N., Ando, W., & Pezzotti, G. (2022). PCA-assisted Raman analysis of osteonecrotic human femoral heads. Methods and Protocols, 5(1), 10. https://doi.org/10.3390/mps5010010
Kagami, H., Inoue, M., Kobayashi, A., Taguchi, A., Li, X., & Yoshizawa, M. (2018). Issues with the surgical treatment of antiresorptive agent-related osteonecrosis of the jaws. Oral Diseases, 24(1-2), 52-56. https://doi.org/10.1111/odi.12783
Khalid, M., Bora, T., Ghaithi, A. A., Thukral, S., & Dutta, J. (2018). Raman spectroscopy detects changes in bone mineral quality and collagen cross-linkage in Staphylococcus infected human bone. Scientific Reports, 8(1), 9417. https://doi.org/10.1038/s41598-018-27752-z
Khan, A. A., Morrison, A., Hanley, D. A., Felsenberg, D., McCauley, L. K., O'Ryan, F., Reid, I. R., Ruggiero, S. L., Taguchi, A., Tetradis, S., Watts, N. B., Brandi, M. L., Peters, E., Guise, T., Eastell, R., Cheung, A. M., Morin, S. N., Masri, B., Cooper, C., … International Task Force on Osteonecrosis of the Jaw. (2015). Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus. Journal of Bone and Mineral Research, 30(1), 3-23. https://doi.org/10.1002/jbmr.2405
Kiefer, J. (2014). Instantaneous shifted-excitation Raman difference spectroscopy (iSERDS). Journal of Raman Spectroscopy, 45(10), 980-983. https://doi.org/10.1002/jrs.4566
Kim, H., Drake, B. L., & Park, H. (2007). Multiclass classifiers based on dimension reduction with generalized LDA. Pattern Recognition, 40(11), 2939-2945. https://doi.org/10.1016/j.patcog.2007.03.002
Kimura-Suda, H., & Ito, T. (2017). Bone quality characteristics obtained by Fourier transform infrared and Raman spectroscopic imaging. Journal of Oral Biosciences, 59(3), 142-145. https://doi.org/10.1016/j.job.2017.04.002
Kreiß, L., Hohmann, M., Klämpfl, F., Schürmann, S., Dehghani, F., Schmidt, M., Friedrich, O., & Büchler, L. (2019). Diffuse reflectance spectroscopy and Raman spectroscopy for label-free molecular characterization and automated detection of human cartilage and subchondral bone. Sensors and Actuators B: Chemical, 301, 127121. https://doi.org/10.1016/j.snb.2019.127121
Kün-Darbois, J. D., Libouban, H., Mabilleau, G., Pascaretti-Grizon, F., & Chappard, D. (2018). Bone mineralization and vascularization in bisphosphonate-related osteonecrosis of the jaw: An experimental study in the rat. Clinical Oral Investigations, 22(9), 2997-3006. https://doi.org/10.1007/s00784-018-2385-2
Maher, J. R., Chuchuen, O., Henderson, M. H., Kim, S., Rinehart, M. T., Kashuba, A. D., Wax, A., & Katz, D. F. (2015). Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue. Biomedical Optics Express, 6(6), 2022-2035. https://doi.org/10.1364/BOE.6.002022
Maiwald, M., Muller, A., Sumpf, B., Erbert, G., & Trankle, G. (2015). Capability of shifted excitation Raman difference spectroscopy under ambient daylight. Applied Optics, 54(17), 5520-5524. https://doi.org/10.1364/AO.54.005520
Marx, R. E. (2003). Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. Journal of Oral and Maxillofacial Surgery, 61(9), 1115-1117. https://doi.org/10.1016/s0278-2391(03)00720-1
Matthies, L., Gebrekidan, M. T., Tegtmeyer, J. F., Oetter, N., Rohde, M., Vollkommer, T., Smeets, R., Wilczak, W., Stelzle, F., Gosau, M., Braeuer, A. S., & Knipfer, C. (2021). Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy. Biomedical Optics Express, 12(2), 836-851. https://doi.org/10.1364/BOE.409456
Mehari, F., Rohde, M., Knipfer, C., Kanawade, R., Klämpfl, F., Adler, W., Stelzle, F., & Schmidt, M. (2014). Laser induced breakdown spectroscopy for bone and cartilage differentiation-ex vivo study as a prospect for a laser surgery feedback mechanism. Biomedical Optics Express, 5(11), 4013-4023.
Morris, M. D., & Mandair, G. S. (2011). Raman assessment of bone quality. Clinical Orthopaedics and Related Research, 469(8), 2160-2169. https://doi.org/10.1007/s11999-010-1692-y
Müller, M. G., Valdez, T. A., Georgakoudi, I., Backman, V., Fuentes, C., Kabani, S., Laver, N., Wang, Z., Boone, C. W., Dasari, R. R., Shapshay, S. M., & Feld, M. S. (2003). Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma. Cancer, 97(7), 1681-1692. https://doi.org/10.1002/cncr.11255
Neumann, H., Langner, C., Neurath, M. F., & Vieth, M. (2012). Confocal laser endomicroscopy for diagnosis of Barrett's esophagus. Frontiers in Oncology, 2, 42. https://doi.org/10.3389/fonc.2012.00042
Nicolatou-Galitis, O., Papadopoulou, E., Vardas, E., Kouri, M., Galiti, D., Galitis, E., Alexiou, K. E., Tsiklakis, K., Ardavanis, A., Razis, E., Athanasiadis, I., Droufakou, S., Psyrri, A., Karamouzis, M. V., Linardou, H., Daliani, D., Tzanninis, D., Sachanas, S., Laschos, K., … Ripamonti, C. I. (2020). Alveolar bone histological necrosis observed prior to extractions in patients, who received bone-targeting agents. Oral Diseases, 26(5), 955-966. https://doi.org/10.1111/odi.13294
Nieuwoudt, M. K., Shahlori, R., Naot, D., Patel, R., Holtkamp, H., Aguergaray, C., Watson, M., Musson, D., Brown, C., Dalbeth, N., Cornish, J., & Simpson, M. C. (2020). Raman spectroscopy reveals age- and sex-related differences in cortical bone from people with osteoarthritis. Scientific Reports, 10(1), 19443. https://doi.org/10.1038/s41598-020-76337-2
Noack, K., Eskofier, B., Kiefer, J., Dilk, C., Bilow, G., Schirmer, M., Buchholz, R., & Leipertz, A. (2013). Combined shifted-excitation Raman difference spectroscopy and support vector regression for monitoring the algal production of complex polysaccharides. Analyst, 138(19), 5639-5646. https://doi.org/10.1039/c3an01158e
Nyman, J. S., Makowski, A. J., Patil, C. A., Masui, T. P., O'Quinn, E. C., Bi, X., Guelcher, S. A., Nicollela, D. P., & Mahadevan-Jansen, A. (2011). Measuring differences in compositional properties of bone tissue by confocal Raman spectroscopy. Calcified Tissue International, 89(2), 111-122. https://doi.org/10.1007/s00223-011-9497-x
Oetter, N., Knipfer, C., Rohde, M., von Wilmowsky, C., Maier, A., Brunner, K., Adler, W., Neukam, F. W., Neumann, H., & Stelzle, F. (2016). Development and validation of a classification and scoring system for the diagnosis of oral squamous cell carcinomas through confocal laser endomicroscopy. Journal of Translational Medicine, 14(1), 159. https://doi.org/10.1186/s12967-016-0919-4
Okagbare, P. I., Begun, D., Tecklenburg, M., Awonusi, A., Goldstein, S. A., & Morris, M. D. (2012). Noninvasive Raman spectroscopy of rat tibiae: Approach to in vivo assessment of bone quality. Journal of Biomedical Optics, 17(9), 90502. https://doi.org/10.1117/1.JBO.17.9.090502
Olejnik, C., Falgayrac, G., During, A., Vieillard, M. H., Maes, J. M., Cortet, B., & Penel, G. (2014). Molecular alterations of bone quality in sequesters of bisphosphonates-related osteonecrosis of the jaws. Osteoporosis International, 25(2), 747-756. https://doi.org/10.1007/s00198-013-2514-3
Oliveira, A. P., Bitar, R. A., Silveira, L., Zangaro, R. A., & Martin, A. A. (2006). Near-infrared Raman spectroscopy for oral carcinoma diagnosis. Photomedicine and Laser Surgery, 24(3), 348-353. https://doi.org/10.1089/pho.2006.24.348
Onizawa, K., Okamura, N., Saginoya, H., Yusa, H., Yanagawa, T., & Yoshida, H. (2002). Analysis of fluorescence in oral squamous cell carcinoma. Oral Oncology, 38(4), 343-348. https://doi.org/10.1016/s1368-8375(01)00070-7
Otto, S., Pautke, C., Van den Wyngaert, T., Niepel, D., & Schiodt, M. (2018). Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases. Cancer Treatment Reviews, 69, 177-187. https://doi.org/10.1016/j.ctrv.2018.06.007
Pascart, T., Falgayrac, G., Cortet, B., Paccou, J., Bleuse, M., Coursier, R., Putman, S., Quinchon, J. F., Bertheaume, N., Delattre, J., Marchandise, P., Cultot, A., Norberciak, L., Kerckhofs, G., & Budzik, J. F. (2022). Subchondral involvement in osteonecrosis of the femoral head: Insight on local composition, microstructure and vascularization. Osteoarthritis and Cartilage, 30(8), 1103-1115. https://doi.org/10.1016/j.joca.2022.05.003
Pascart, T., Falgayrac, G., Migaud, H., Quinchon, J. F., Norberciak, L., Budzik, J. F., Paccou, J., Cotten, A., Penel, G., & Cortet, B. (2017). Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis. Scientific Reports, 7(1), 97. https://doi.org/10.1038/s41598-017-00162-3
Pautke, C., Bauer, F., Otto, S., Tischer, T., Steiner, T., Weitz, J., Kreutzer, K., Hohlweg-Majert, B., Wolff, K. D., Hafner, S., Mast, G., Ehrenfeld, M., Stürzenbaum, S. R., & Kolk, A. (2011). Fluorescence-guided bone resection in bisphosphonate-related osteonecrosis of the jaws: First clinical results of a prospective pilot study. Journal of Oral and Maxillofacial Surgery, 69(1), 84-91. https://doi.org/10.1016/j.joms.2010.07.014
Penel, G., Delfosse, C., Descamps, M., & Leroy, G. (2005). Composition of bone and apatitic biomaterials as revealed by intravital Raman microspectroscopy. Bone, 36(5), 893-901. https://doi.org/10.1016/j.bone.2005.02.012
Qaisi, M., & Montague, L. (2017). Bone margin analysis for osteonecrosis and osteomyelitis of the jaws. Oral and Maxillofacial Surgery Clinics of North America, 29(3), 301-313. https://doi.org/10.1016/j.coms.2017.03.007
Register, J., Maiwald, M., Fales, A., Strobbia, P., Sumpf, B., & Vo-Dinh, T. (2018). Shifted-excitation Raman difference spectroscopy for the detection of SERS-encoded gold nanostar probes. Journal of Raman Spectroscopy, 49(12), 1961-1967. https://doi.org/10.1002/jrs.5482
Ristow, O., Otto, S., Troeltzsch, M., Hohlweg-Majert, B., & Pautke, C. (2015). Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ). Journal of Cranio-Maxillo-Facial Surgery, 43(2), 290-293. https://doi.org/10.1016/j.jcms.2014.11.014
Ristow, O., & Pautke, C. (2014). Auto-fluorescence of the bone and its use for delineation of bone necrosis. International Journal of Oral and Maxillofacial Surgery, 43(11), 1391-1393. https://doi.org/10.1016/j.ijom.2014.07.017
Rolvien, T., Krause, M., Jeschke, A., Yorgan, T., Püschel, K., Schinke, T., Busse, B., Demay, M. B., & Amling, M. (2017). Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone. Bone, 103, 78-87. https://doi.org/10.1016/j.bone.2017.06.022
Ruggiero, S. L., Dodson, T. B., Aghaloo, T., Carlson, E. R., Ward, B. B., & Kademani, D. (2022). American Association of Oral and Maxillofacial Surgeons' position paper on medication-related osteonecrosis of the jaws-2022 update. Journal of Oral and Maxillofacial Surgery, 80(5), 920-943. https://doi.org/10.1016/j.joms.2022.02.008
Russo, M., Tirinato, L., Scionti, F., Coluccio, M. L., Perozziello, G., Riillo, C., Mollace, V., Gratteri, S., Malara, N., di Martino, M. T., Viglietto, G., Tagliaferri, P., Tassone, P., Rossi, M., & Candeloro, P. (2020). Raman spectroscopic stratification of multiple myeloma patients based on exosome profiling. ACS Omega, 5(47), 30436-30443. https://doi.org/10.1021/acsomega.0c03813
Schiegnitz, E., Al-Nawas, B., Hoefert, S., Otto, S., Pautke, C., Ristow, O., Voss, P., & Grötz, K. (2018). S3-Leitlinie Antiresorptiva-Assoziierte Kiefernekrosen (AR-ONJ). AWMF Online, 007, 91.
Shah, F. A. (2020). Towards refining Raman spectroscopy-based assessment of bone composition. Scientific Reports, 10(1), 16662. https://doi.org/10.1038/s41598-020-73559-2
Shah, F. A., Stoica, A., Cardemil, C., & Palmquist, A. (2018). Multiscale characterization of cortical bone composition, microstructure, and nanomechanical properties in experimentally induced osteoporosis. Journal of Biomedical Materials Research: Part A, 106(4), 997-1007. https://doi.org/10.1002/jbm.a.36294
Shreve, A. P., Cherepy, N. J., & Mathies, R. A. (2016). Effective rejection of fluorescence interference in Raman spectroscopy using a shifted excitation difference technique. Applied Spectroscopy, 46(4), 707-711. https://doi.org/10.1366/0003702924125122
Spanou, A., Lyritis, G. P., Chronopoulos, E., & Tournis, S. (2015). Management of bisphosphonate-related osteonecrosis of the jaw: A literature review. Oral Diseases, 21(8), 927-936. https://doi.org/10.1111/odi.12333
Thomas, D. B., Fordyce, R. E., Frew, R. D., & Gordon, K. C. (2007). A rapid, non-destructive method of detecting diagenetic alteration in fossil bone using Raman spectroscopy. Journal of Raman Spectroscopy, 38(12), 1533-1537. https://doi.org/10.1002/jrs.1851
Timlin, J. A., Carden, A., Morris, M. D., Rajachar, R. M., & Kohn, D. H. (2000). Raman spectroscopic imaging markers for fatigue-related microdamage in bovine bone. Analytical Chemistry, 72(10), 2229-2236. https://doi.org/10.1021/ac9913560
Tzaphlidou, M. (2008). Bone architecture: Collagen structure and calcium/phosphorus maps. Journal of Biological Physics, 34(1-2), 39-49. https://doi.org/10.1007/s10867-008-9115-y
Unal, M., Ahmed, R., Mahadevan-Jansen, A., & Nyman, J. S. (2021). Compositional assessment of bone by Raman spectroscopy. Analyst, 146(24), 7464-7490. https://doi.org/10.1039/d1an01560e
Vohra, P., Strobbia, P., Ngo, H. T., Lee, W. T., & Vo-Dinh, T. (2018). Rapid Nanophotonics assay for head and neck cancer diagnosis. Scientific Reports, 8(1), 11410. https://doi.org/10.1038/s41598-018-29428-0
Wehrhan, F., Weber, M., Neukam, F. W., Geppert, C. I., Kesting, M., & Preidl, R. H. M. (2019). Fluorescence-guided bone resection: A histological analysis in medication-related osteonecrosis of the jaw. Journal of Cranio-Maxillo-Facial Surgery, 47(10), 1600-1607. https://doi.org/10.1016/j.jcms.2019.07.012
Weitzman, R., Sauter, N., Eriksen, E. F., Tarassoff, P. G., Lacerna, L. V., Dias, R., Altmeyer, A., Csermak-Renner, K., McGrath, L., Lantwicki, L., & Hohneker, J. A. (2007). Critical review: Updated recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in cancer patients-May 2006. Critical Reviews in Oncology/Hematology, 62(2), 148-152. https://doi.org/10.1016/j.critrevonc.2006.12.005
Yerramshetty, J. S., & Akkus, O. (2008). The associations between mineral crystallinity and the mechanical properties of human cortical bone. Bone, 42(3), 476-482. https://doi.org/10.1016/j.bone.2007.12.001
Yoshioka, Y., Yamachika, E., Nakanishi, M., Ninomiya, T., Nakatsuji, K., Matsubara, M., Moritani, N., Kobayashi, Y., Fujii, T., & Iida, S. (2018). Molecular alterations of newly formed mandibular bone caused by zoledronate. International Journal of Oral and Maxillofacial Surgery, 47(9), 1206-1213. https://doi.org/10.1016/j.ijom.2018.02.002