Increased D-dimer and fibrin degradation product levels as potential indicators for evaluating infection-related acute urticaria: a case-case-control study.
D-dimer
Fibrin degradation product
Urticaria
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
15
05
2023
accepted:
13
08
2023
revised:
21
06
2023
medline:
1
11
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
ppublish
Résumé
About 20% of world population suffer from acute urticaria at some stage in their lives. Recent studies showed coagulation dysfunction in chronic urticaria. The involvement of coagulation changes in acute urticaria remains unclear. Fifty-eight acute urticaria patients were enrolled in this study and divided into two groups (referred to throughout as infection-related and infection-unrelated acute urticaria). The routine laboratory parameters including coagulation tests between the two groups were compared. The correlation between coagulation tests and CRP at acute phase was also assessed. Dynamic change of routine coagulation test results at acute phase and resolving phase was compared. The potential performance of coagulation for infection indication was tested. We found D-dimer, fibrin degradation product (FDP), and fibrinogen (Fg) increased in the acute phase of infection-related acute urticaria patients. D-dimer, FDP, Fg, and APTT are positively correlated with CRP in the acute phase. D-dimer and FDP decreased in the resolving phase of infection-related acute urticaria patients. Higher D-dimer (> 0.48 mg/L) and FDP (> 3.84 mg/L) may indicate infection-related acute urticaria. In conclusion, in acute urticaria with low venous thromboembolism risk, D-dimer level and dynamic change can be potentially used for the infection-related clinical practice management.
Identifiants
pubmed: 37650955
doi: 10.1007/s00403-023-02706-2
pii: 10.1007/s00403-023-02706-2
doi:
Substances chimiques
fibrin fragment D
0
Fibrin Fibrinogen Degradation Products
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2871-2876Subventions
Organisme : Young Science and Technology Project
ID : 2022KJXX-26
Organisme : National Natural Science Foundation of China
ID : 82102416
Organisme : National Natural Science Foundation of China
ID : 82202635
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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