Neurotrophic neolignans of Pinus koraiensis twigs.

Lignans / pharmacology Pinus Molecular Structure Circular Dichroism Nitric Oxide
Anti-inflammation Neolignan Neurotrophic Pinaceae Pinus koraiensis

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 11 07 2023
revised: 29 08 2023
accepted: 29 08 2023
medline: 29 9 2023
pubmed: 1 9 2023
entrez: 31 8 2023
Statut: ppublish

Résumé

Four undescribed neolignan analogs, together with eight known compounds, were isolated from the twigs of Pinus koraiensis (Korean pine). The chemical structure of the isolated compounds was determined through extensive spectroscopic analysis and chemical method. Their relative and absolute configurations were assigned through a well-established empirical rule and electronic circular dichroism (ECD) analysis, respectively. Four compounds (3 and 9-11) at 20 μM concentration showed significant neurotrophic effect by inducing nerve growth factor (NGF) secretion in C6 cells with the stimulation levels a range of 140.82 ± 4.62% to 160.04 ± 11.04%. Additionally, the result indicated that the glycosylation of neolignan led to an improvement in neurotrophic activity compared to their aglycone form. A compound (7) inhibited nitric oxide production with an IC

Identifiants

DOI: 10.1016/j.fitote.2023.105664 PMID: 37652269
pubmed: 37652269
pii: S0367-326X(23)00239-3
doi: 10.1016/j.fitote.2023.105664
pii:
doi:

Substances chimiques

Lignans 0
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105664

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Kyoung Jin Park (KJ)

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Zahra Khan (Z)

Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea; College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.

Seong-Min Hong (SM)

Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea; College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.

Sun Yeou Kim (SY)

Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea; College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.

Kang Ro Lee (KR)

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: krlee@skku.edu.

Chung Sub Kim (CS)

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: chungsub.kim@skku.edu.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Lignanes › Neurotrophic neolignans of Pinus koraiensis twigs.
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Pinales › Pinaceae › Pinus › Neurotrophic neolignans of Pinus koraiensis twigs.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Neurotrophic neolignans of Pinus koraiensis twigs.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Dichroïsme circulaire › Neurotrophic neolignans of Pinus koraiensis twigs.
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Neurotrophic neolignans of Pinus koraiensis twigs.