PET Imaging and Protein Expression of Prostate-Specific Membrane Antigen in Glioblastoma: A Multicenter Inventory Study.
PET
RNA sequencing
glioblastoma
immunohistochemistry
prostate-specific membrane antigen (PSMA)
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
16
03
2023
revised:
31
05
2023
medline:
5
10
2023
pubmed:
1
9
2023
entrez:
31
8
2023
Statut:
ppublish
Résumé
Upregulation of prostate-specific membrane antigen (PSMA) in neovasculature has been described in glioblastoma multiforme (GBM), whereas vasculature in nonaffected brain shows hardly any expression of PSMA. It is unclear whether PSMA-targeting tracer uptake on PET is based on PSMA-specific binding to neovasculature or aspecific uptake in tumor. Here, we quantified uptake of various PSMA-targeting tracers in GBM and correlated this with PSMA expression in tumor biopsy samples from the same patients.
Identifiants
pubmed: 37652540
pii: jnumed.123.265738
doi: 10.2967/jnumed.123.265738
doi:
Substances chimiques
Gallium Radioisotopes
0
Types de publication
Multicenter Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1526-1531Informations de copyright
© 2023 by the Society of Nuclear Medicine and Molecular Imaging.