No evidence of asymptomatic monkeypox infection in a highly sexually active MSM population in Austria.
STI screening
anal swabs
asymptomatic infection
men who have sex with men
Journal
HIV medicine
ISSN: 1468-1293
Titre abrégé: HIV Med
Pays: England
ID NLM: 100897392
Informations de publication
Date de publication:
31 Aug 2023
31 Aug 2023
Historique:
received:
19
06
2023
accepted:
06
08
2023
medline:
1
9
2023
pubmed:
1
9
2023
entrez:
31
8
2023
Statut:
aheadofprint
Résumé
The 2022 outbreak of monkeypox virus (MPXV) revealed new transmission routes. Incidence declined sharply in September 2022, and it remains unclear whether MPXV is circulating in asymptomatic individuals because of increased immunity. Our study aimed to assesss the number of asymtomatic MPXV carriers in individuals at high risk for STI. We analysed anal samples from asymptomatic highly sexually active men who have sex with men for the presence of MPXV. We detected a high number of concomitant sexually transmitted infections but did not find a single sample with MPXV. Our results indicate that the general recommendation to implement screening for MPXV is not currently justified.
Sections du résumé
BACKGROUND
BACKGROUND
The 2022 outbreak of monkeypox virus (MPXV) revealed new transmission routes. Incidence declined sharply in September 2022, and it remains unclear whether MPXV is circulating in asymptomatic individuals because of increased immunity.
OBJECTIVES
OBJECTIVE
Our study aimed to assesss the number of asymtomatic MPXV carriers in individuals at high risk for STI.
METHODS
METHODS
We analysed anal samples from asymptomatic highly sexually active men who have sex with men for the presence of MPXV.
RESULTS
RESULTS
We detected a high number of concomitant sexually transmitted infections but did not find a single sample with MPXV.
CONCLUSIONS
CONCLUSIONS
Our results indicate that the general recommendation to implement screening for MPXV is not currently justified.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Scientific Fund of the Major of Vienna
Informations de copyright
© 2023 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.
Références
Thornhill JP, Barkati S, Walmsley S, et al. Monkeypox virus infection in humans across 16 countries. N Engl J Med. 2022;387(8):679-691. doi:10.1056/NEJMoa2207323
Angelo KM, Smith T, Camprubí-Ferrer D, et al. Epidemiological and clinical characteristics of patients with monkeypox in the GeoSentinel network: a cross-sectional study. Lancet Infect Dis. 2023;23(2):196-206. doi:10.1016/S1473-3099(22)00651-X
Antinori A, Mazzotta V, Vita S, et al. Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy. Euro Surveill. 2022;27(22):2200421. doi:10.2807/1560-7917.ES.2022.27.22.2200421
Iñigo Martínez J, Gil Montalbán E, Jiménez Bueno S, et al. Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain. Euro Surveill. 2022;27(27):2200471. doi:10.2807/1560-7917.ES.2022.27.27.2200471
Vivancos R, Anderson C, Blomquist P, et al. Monkeypox incident management team. Community transmission of monkeypox in the United Kingdom. Euro Surveill. 2022;27(22):2200422. doi:10.2807/1560-7917.ES.2022.27.22.2200422
Hoffmann C, Jessen H, Wyen C, et al. Clinical characteristics of monkeypox virus infections among men with and without HIV: a large outbreak cohort in Germany. HIV Med. 2023;24(4):389-397. doi:10.1111/hiv.13378
Peiró-Mestres A, Fuertes I, Camprubí-Ferrer D, et al. Frequent detection of monkeypox virus DNA in saliva, semen, and other clinical samples from 12 patients, Barcelona, Spain. Euro Surveill. 2022;27(28):2200503. doi:10.2807/1560-7917.ES.2022.27.28.2200503
Lapa D, Carletti F, Mazzotta V, et al. Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding. Lancet Infect Dis. 2022;22(9):1267-1269. doi:10.1016/S1473-3099(22)00513-8
Delaney KP, Sanchez T, Hannah M, et al. Strategies adopted by gay, bisexual, and other men who have sex with men to prevent monkeypox virus transmission-United States. MMWR Morb Mortal Wkly Rep. 2022;71(35):1126-1130. doi:10.15585/mmwr.mm7135e1
Endo A, Murayama H, Abbott S, et al. Heavy-tailed sexual contact networks and monkeypox epidemiology in the global outbreak. Science. 2022;378(6615):90-94. doi:10.1126/science.add4507
De Baetselier I, Van Dijck C, Kenyon C, et al. ITM monkeypox study group. Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium. Nat Med. 2022;28(11):2288-2292. doi:10.1038/s41591-022-02004-w
Palich R, Burrel S, Monsel G, et al. Viral loads in clinical samples of men with monkeypox virus infection: a French case series. Lancet Infect Dis. 2023;23(1):74-80. doi:10.1016/S1473-3099(22)00586-2
Wilber E, Rebolledo PA, Kasinathan V, et al. Utility of a viral vesicular panel multiplex polymerase chain reaction assay for the diagnosis of monkeypox, herpes simplex, and varicella zoster viruses. Open Forum Infectious Diseases. 2023;10(3):ofad140. doi:10.1093/ofid/ofad140
van de Vijver D. Modelling the risk of future MPOX outbreaks in The Netherlandsthe Netherlands, CROI 2023, Poster 926.
Guagliardo SAJ, Monroe B, Moundjoa C, et al. Asymptomatic Orthopoxvirus circulation in humans in the wake of a monkeypox outbreak among chimpanzees in Cameroon. Am J Trop Med Hyg. 2020;102(1):206-212. doi:10.4269/ajtmh.19-0467
Jezek Z, Marennikova SS, Mutumbo M, Nakano JH, Paluku KM, Szczeniowski M. Human monkeypox: a study of 2,510 contacts of 214 patients. J Infect Dis. 1986;154(4):551-555. doi:10.1093/infdis/154.4.551
Rimoin AW, Mulembakani PM, Johnston SC, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A. 2010;107(37):16262-16267. doi:10.1073/pnas.1005769107
Payne AB, Ray LC, Cole MM, et al. Reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons-43 U.S. jurisdictions. MMWR Morb Mortal Wkly Rep. 2022;71(49):1560-1564. doi:10.15585/mmwr.mm7149a5
Thy M, Peiffer-Smadja N, Mailhe M, et al. Breakthrough infections after postexposure vaccination against Mpox. N Engl J Med. 2022;387(26):2477-2479. doi:10.1056/NEJMc2211944
Golden J, Harryman L, Crofts M, et al. Case of apparent mpox reinfection. Sex Transm Infect. 2023;99:283-284. doi:10.1136/sextrans-2022-055736
Musumeci S, Najjar I, Boffi El Amari E, et al. A case of mpox reinfection. Clin Infect Dis. 2023;11:ciad147. doi:10.1093/cid/ciad147
Ogale YP, Baird N, Townsend MB, et al. Evidence of mpox virus infection among persons without characteristic lesions or rash presenting for first dose of JYNNEOS vaccine-District of Columbia. Clin Infect Dis. 2023;77(2):298-302. doi:10.1093/cid/ciad145