Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease.

Journal

NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390

Informations de publication

Date de publication:
31 Aug 2023
Historique:
received: 25 05 2023
accepted: 16 08 2023
medline: 1 9 2023
pubmed: 1 9 2023
entrez: 31 8 2023
Statut: epublish

Résumé

The genetic basis of levodopa-induced-dyskinesia (LiD) is poorly understood, and there have been few well-powered genome-wide studies. We performed a genome-wide survival meta-analyses to study the effect of genetic variation on the development of LiD in five separate longitudinal cohorts, and meta-analysed the results. We included 2784 PD patients, of whom 14.6% developed LiD. We found female sex (HR = 1.35, SE = 0.11, P = 0.007) and younger age at onset (HR = 1.8, SE = 0.14, P = 2 × 10

Identifiants

DOI: 10.1038/s41531-023-00573-2 PMID: 37652906 PMC: PMC10471743
pubmed: 37652906
doi: 10.1038/s41531-023-00573-2
pii: 10.1038/s41531-023-00573-2
pmc: PMC10471743
doi:

Types de publication

Journal Article

Langues

eng

Pagination

128

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Alejandro Martinez-Carrasco (A)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK. alejandro.carrasco.20@ucl.ac.uk.
UCL Movement Disorders Centre, University College London, London, UK. alejandro.carrasco.20@ucl.ac.uk.
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. alejandro.carrasco.20@ucl.ac.uk.
ORCID: 0000-0001-6191-1703

Raquel Real (R)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
UCL Movement Disorders Centre, University College London, London, UK.
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
ORCID: 0000-0001-8117-742X

Michael Lawton (M)

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-3419-0354

Hirotaka Iwaki (H)

Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Data Tecnica International, Glen Echo, MD, USA.

Manuela M X Tan (MMX)

Department of Neurology, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-5835-669X

Lesley Wu (L)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
UCL Movement Disorders Centre, University College London, London, UK.
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.

Nigel M Williams (NM)

Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
ORCID: 0000-0003-1177-6931

Camille Carroll (C)

Faculty of Health, University of Plymouth, Plymouth, UK.
Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.

Michele T M Hu (MTM)

Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, UK.
Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK.

Donald G Grosset (DG)

School of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.

John Hardy (J)

Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
UK Dementia Research Institute, University College London, London, UK.
Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre, London, UK.
Institute for Advanced Study, The Hong Kong University of Science and Technology, Hong Kong SAR, China.

Mina Ryten (M)

Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.
ORCID: 0000-0001-9520-6957

Tom Foltynie (T)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
ORCID: 0000-0003-0752-1813

Yoav Ben-Shlomo (Y)

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Maryam Shoai (M)

Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
UK Dementia Research Institute, University College London, London, UK.

Huw R Morris (HR)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK. h.morris@ucl.ac.uk.
UCL Movement Disorders Centre, University College London, London, UK. h.morris@ucl.ac.uk.
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. h.morris@ucl.ac.uk.
ORCID: 0000-0002-5473-3774

Classifications MeSH