Gut microbiota and microbiota-derived metabolites in colorectal cancer: enemy or friend.
Cancer immunity
Cancer metabolism
Colorectal cancer
Gut microbiota
Inflammation
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
received:
16
07
2023
accepted:
27
08
2023
medline:
4
9
2023
pubmed:
1
9
2023
entrez:
31
8
2023
Statut:
epublish
Résumé
Colorectal cancer (CRC) is a highly prevalent gastrointestinal cancer worldwide. Recent research has shown that the gut microbiota plays a significant role in the development of CRC. There is mounting evidence supporting the crucial contributions of bacteria-derived toxins and metabolites to cancer-related inflammation, immune imbalances, and the response to therapy. Besides, some gut microbiota and microbiota-derived metabolites have protective effects against CRC. This review aims to summarize the current studies on the effects and mechanisms of gut microbiota and microbiota-produced metabolites in the initiation, progression, and drug sensitivity/resistance of CRC. Additionally, we explore the clinical implications and future prospects of utilizing gut microbiota as innovative approaches for preventing and treating CRC.
Identifiants
pubmed: 37653349
doi: 10.1007/s11274-023-03742-w
pii: 10.1007/s11274-023-03742-w
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
291Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
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