Bilirubin in wound healing: A double-edged sword.
antioxidant
bilirubin
heme
hydrogen peroxide
reactive oxygen species
wound healing
Journal
Cell biochemistry and function
ISSN: 1099-0844
Titre abrégé: Cell Biochem Funct
Pays: England
ID NLM: 8305874
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
27
07
2023
received:
17
05
2023
accepted:
24
08
2023
pubmed:
1
9
2023
medline:
1
9
2023
entrez:
1
9
2023
Statut:
ppublish
Résumé
The impact of bilirubin levels on wound healing remains a topic of controversy. The present study is a literature review that examines the impact of increased levels of bilirubin in the bloodstream on the process of wound healing. The physiological pathways and their interrelationships, as well as the relevant research publications, were comprehensively addressed in our discussion. The present study undertook a comprehensive review of the extant literature pertaining to the impact of bilirubin concentration on the process of wound healing, with particular emphasis on its association with reactive oxygen species. This scholarly article provides an overview of several studies that elucidate the mechanisms and correlation between bilirubin and the process of wound healing. The impact of bilirubin on wound healing has been observed, and it appears to function as a modulator. This review demonstrates that there exists a spectrum of bilirubin concentrations that can function as precise regulators, although this range falls under pathological hyperbilirubinemia. Further research is required to determine the precise boundary of this range. Within a certain range, bilirubin serves as a positive regulator in the process of wound healing. Beyond this range, it has the potential to function as a negative regulator.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
953-958Informations de copyright
© 2023 John Wiley & Sons Ltd.
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