Salivary Soluble CD44 Level in Chronic Periodontitis - A Comparative Assessment between Preoperative and Postoperative Scaling and Root Planing.
Chronic periodontitis
gingival index
plaque index
probing depth
salivary sCD44
scaling and root planning
Journal
Journal of pharmacy & bioallied sciences
ISSN: 0976-4879
Titre abrégé: J Pharm Bioallied Sci
Pays: India
ID NLM: 101537209
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
16
11
2022
revised:
03
01
2023
accepted:
03
01
2023
medline:
1
9
2023
pubmed:
1
9
2023
entrez:
1
9
2023
Statut:
ppublish
Résumé
Salivary biomarkers can be used to diagnose illnesses, track their course, and gauge a patient's response to therapy. Inflammatory circumstances result in higher sCD44 levels. The most typical inflammatory disorder connected to periodontal tissue is called periodontitis. Therefore, the purpose "of the current study was to compare the levels of sCD44 in patients with chronic periodontitis before and after scaling and root planing. 1) Determining CD44 concentrations in healthy individuals' spit. 2) To quantify CD44 levels in the saliva of individuals with persistent periodontitis. The third objective is to compare the levels of CD44 that can be dissolved in saliva between those with healthy gums and those with active periodontitis. 4) Assessing CD44 levels in saliva after "scaling and root planing in patients with chronic periodontitis." Half of the study participants were classified as having chronic periodontitis, while the other half had healthy gums. Participants with healthy gums and those with chronic periodontitis had their plaque levels, gingival status, and testing depths measured. All the same, data were calculated in persons with chronic periodontitis one month after they had "scaling and root planing done. Clinical attachment levels were evaluated before scaling and root planing was performed on patients with chronic periodontitis and again one month afterwards. Patients with chronic periodontitis," those whose condition had not improved following scaling and root planing (SRP), and healthy individuals all had spit tests conducted after a month. The concentration of sCD44 in the saliva was determined with a chemically coupled immunosorbent assay. Salivary sCD44 levels were substantially greater in people with chronic periodontitis than in people without the condition. After one month of scaling and root planing in patients with chronic periodontitis, sCD44 levels drastically dropped (p < 0.0001). Chronic periodontitis is linked to elevated levels of salivary sCD44. sCD44 can be employed as a possible salivary biomarker for chronic Periodontitis.
Sections du résumé
Background
UNASSIGNED
Salivary biomarkers can be used to diagnose illnesses, track their course, and gauge a patient's response to therapy. Inflammatory circumstances result in higher sCD44 levels. The most typical inflammatory disorder connected to periodontal tissue is called periodontitis. Therefore, the purpose "of the current study was to compare the levels of sCD44 in patients with chronic periodontitis before and after scaling and root planing.
Objectives
UNASSIGNED
1) Determining CD44 concentrations in healthy individuals' spit. 2) To quantify CD44 levels in the saliva of individuals with persistent periodontitis. The third objective is to compare the levels of CD44 that can be dissolved in saliva between those with healthy gums and those with active periodontitis. 4) Assessing CD44 levels in saliva after "scaling and root planing in patients with chronic periodontitis."
Materials and Methods
UNASSIGNED
Half of the study participants were classified as having chronic periodontitis, while the other half had healthy gums. Participants with healthy gums and those with chronic periodontitis had their plaque levels, gingival status, and testing depths measured. All the same, data were calculated in persons with chronic periodontitis one month after they had "scaling and root planing done. Clinical attachment levels were evaluated before scaling and root planing was performed on patients with chronic periodontitis and again one month afterwards. Patients with chronic periodontitis," those whose condition had not improved following scaling and root planing (SRP), and healthy individuals all had spit tests conducted after a month. The concentration of sCD44 in the saliva was determined with a chemically coupled immunosorbent assay.
Results
UNASSIGNED
Salivary sCD44 levels were substantially greater in people with chronic periodontitis than in people without the condition. After one month of scaling and root planing in patients with chronic periodontitis, sCD44 levels drastically dropped (p < 0.0001).
Conclusion
UNASSIGNED
Chronic periodontitis is linked to elevated levels of salivary sCD44. sCD44 can be employed as a possible salivary biomarker for chronic Periodontitis.
Identifiants
pubmed: 37654413
doi: 10.4103/jpbs.jpbs_588_22
pii: JPBS-15-508
pmc: PMC10466655
doi:
Types de publication
Journal Article
Langues
eng
Pagination
S508-S512Informations de copyright
Copyright: © 2023 Journal of Pharmacy and Bioallied Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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