Chromosomal Distribution of Ankylosing Spondylitis Susceptibility Loci.
ankylosing spondylitis
chromosome
genes
susceptibility
Journal
Mediterranean journal of rheumatology
ISSN: 2529-198X
Titre abrégé: Mediterr J Rheumatol
Pays: Greece
ID NLM: 101730166
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
08
08
2022
revised:
30
08
2022
accepted:
03
09
2022
medline:
1
9
2023
pubmed:
1
9
2023
entrez:
1
9
2023
Statut:
epublish
Résumé
Previous studies have been indicated that susceptible loci of several multifactorial diseases were non-randomly distributed on human genome. There is no published data on chromosomal distribution of genes associated with risk of ankylosing spondylitis. Therefore, the present study was carried out. Published meta-analyses indexed in the PubMed database were used in the present study. Non-randomness chromosomal distribution of these loci was evaluated by the statistical method of Tai et al. A total of 88 articles were obtained. There was 32 ankylosing spondylitis associated genes. The present study revealed that the human chromosome segments 6p11.2-p21.33, 19q13.2-q13.42, and 2q11.2-q14.1 were ankylosing spondylitis associated-rich regions by bearing 7, 6 and 4 susceptible loci, respectively. Ankylosing spondylitis associated-genes non-randomly have been distributed non-randomly on human chromosomes.
Identifiants
pubmed: 37654643
doi: 10.31138/mjr.34.2.159
pii: MJR-34-2-159
pmc: PMC10466362
doi:
Types de publication
Journal Article
Langues
eng
Pagination
159-162Informations de copyright
© 2023 The Mediterranean Journal of Rheumatology (MJR).
Déclaration de conflit d'intérêts
The author declares no conflict of interest.
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