Coexistence of Autoimmune Thyroiditis and Juvenile Idiopathic Arthritis.
autoimmune thyroiditis
hashimoto
juvenile idiopathic arthritis
thyroglobulin
thyroid peroxidase
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
accepted:
30
08
2023
medline:
1
9
2023
pubmed:
1
9
2023
entrez:
1
9
2023
Statut:
epublish
Résumé
Autoimmune thyroid disease seems to occur more often in children with juvenile idiopathic arthritis (JIA) than in the general pediatric population. We investigated the prevalence of autoimmune thyroiditis (Hashimoto's thyroiditis) in young patients with JIA in Greece, which has not been evaluated previously. This descriptive study included patients with JIA followed up at the Pediatric Rheumatology Unit of the Second Department of Pediatrics of a tertiary general hospital in Thessaloniki, Greece. All patients were diagnosed and sorted according to the classification criteria of the International League of Associations for Rheumatology. The presence of thyroid autoantibodies was considered for determining autoimmune thyroiditis. Basic demographic, clinical, and laboratory data were collected from patients' records. Results: The analyzed sample comprised 130 patients with JIA (mean age 12.22 years; 69.2% female). Most patients (70%) had a family history of at least one autoimmune disease and 30.8% of Hashimoto's thyroiditis. More than half (53.8%) had enthesitis-related arthritis (ERA), 22.3% had oligoarthritis, and 15.4% had psoriatic arthritis. Thyroid autoantibodies were detected in 22/130 patients (16.9%) suggesting autoimmune thyroiditis; most of these patients were euthyroid, whereas 3/22 (13.6%) had overt hypothyroidism determined by elevated levels of thyroid-stimulating hormone, decreased levels of free thyroxine, and typical ultrasound findings for Hashimoto's thyroiditis. The prevalence of clinical cases of Hashimoto's disease was 2.3%. The prevalence of autoimmune thyroiditis in our JIA cohort is higher compared to the general population and consistent with the previously reported range. Hence, investigation for thyroid autoimmunity should be included in the workup of patients with JIA.
Identifiants
pubmed: 37654906
doi: 10.7759/cureus.44384
pmc: PMC10467609
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e44384Informations de copyright
Copyright © 2023, Sapountzi et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Curr Med Lit Rheumatol. 2013;32(2):33-41
pubmed: 24403667
J Rheumatol. 2019 Feb;46(2):190-197
pubmed: 30275259
Adv Exp Med Biol. 1999;455:55-60
pubmed: 10599323
Pediatr Rheumatol Online J. 2021 Dec 2;19(1):166
pubmed: 34857004
Rheumatology (Oxford). 2005 Apr;44(4):517-20
pubmed: 15695302
Turk J Pediatr. 2008 Sep-Oct;50(5):462-5
pubmed: 19102051
Pediatr Rheumatol Online J. 2020 Jun 5;18(1):43
pubmed: 32503658
Pediatr Rheumatol Online J. 2021 Aug 23;19(1):135
pubmed: 34425842
Clin Exp Rheumatol. 2013 Mar-Apr;31(2):310-7
pubmed: 23406715
Nutrients. 2020 Sep 11;12(9):
pubmed: 32933065
Ital J Pediatr. 2018 Feb 7;44(1):22
pubmed: 29415743
Ital J Pediatr. 2017 Jun 14;43(1):56
pubmed: 28615030
Clin Exp Rheumatol. 2002 Jul-Aug;20(4):565-8
pubmed: 12175117
Front Immunol. 2017 May 09;8:521
pubmed: 28536577
J Rheumatol. 2006 Jan;33(1):164-6
pubmed: 16395764
Front Public Health. 2022 Oct 13;10:1020709
pubmed: 36311599
Autoimmune Dis. 2019 Jul 28;2019:1684074
pubmed: 31467701
Pediatr Rheumatol Online J. 2022 Feb 2;20(1):8
pubmed: 35109858
J Clin Pharm Ther. 2019 Feb;44(1):102-108
pubmed: 30306604
Best Pract Res Clin Endocrinol Metab. 2019 Dec;33(6):101367
pubmed: 31812326
Pediatr Rheumatol Online J. 2023 Feb 21;21(1):19
pubmed: 36810111
RMD Open. 2021 Mar;7(1):
pubmed: 33731444