Daytime Variation in Kidney Perfusion, Oxygenation, and Sodium Concentration Assessed by Multiparametric MRI in Healthy Volunteers.
healthy volunteers
kidney
magnetic resonance imaging
multiparametric
sodium
variation
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
revised:
14
08
2023
received:
16
06
2023
accepted:
15
08
2023
medline:
1
9
2023
pubmed:
1
9
2023
entrez:
1
9
2023
Statut:
aheadofprint
Résumé
MRI can provide information on kidney structure, perfusion, and oxygenation. Furthermore, it allows for the assessment of kidney sodium concentrations and handling, allowing multiparametric evaluation of kidney physiology. Multiparametric MRI is promising for establishing prognosis and monitoring treatment responses in kidney diseases, but its intraindividual variation during the day is unresolved. To investigate the variation in multiparametric MRI measurements from the morning to the evening. Prospective. Ten healthy volunteers, aged 29 ± 5 without history of kidney disease. 3 T/T A multiparametric MRI protocol, yielding T1, R2*, ADC, renal blood flow and renal sodium levels, was acquired in the morning, noon, and evening. The participants were fasting prior to the first examination. Urine biochemical analyses were performed to complement MRI data. The cortex and medulla were analyzed separately in a semi-automatic fashion, and gradients of total sodium concentration (TSC) and R Analyses of variance and mixed-effects models to estimate differences from time of day. Coefficients of variation to assess variability within and between participants. A P-value <0.05 was considered statistically significant. The coefficients of variation varied from 5% to 18% for proton-based parametric sequences, while it was 38% for TSC over a day. Multiparametric MRI is stable over the day. The coefficients of variation over a day were lower for proton multiparametric MRI, but higher for sodium MRI. 2 TECHNICAL EFFICACY: Stage 2.
Sections du résumé
BACKGROUND
BACKGROUND
MRI can provide information on kidney structure, perfusion, and oxygenation. Furthermore, it allows for the assessment of kidney sodium concentrations and handling, allowing multiparametric evaluation of kidney physiology. Multiparametric MRI is promising for establishing prognosis and monitoring treatment responses in kidney diseases, but its intraindividual variation during the day is unresolved.
PURPOSE
OBJECTIVE
To investigate the variation in multiparametric MRI measurements from the morning to the evening.
STUDY TYPE
METHODS
Prospective.
POPULATION
METHODS
Ten healthy volunteers, aged 29 ± 5 without history of kidney disease.
FIELD STRENGTH/SEQUENCE
UNASSIGNED
3 T/T
ASSESSMENT
RESULTS
A multiparametric MRI protocol, yielding T1, R2*, ADC, renal blood flow and renal sodium levels, was acquired in the morning, noon, and evening. The participants were fasting prior to the first examination. Urine biochemical analyses were performed to complement MRI data. The cortex and medulla were analyzed separately in a semi-automatic fashion, and gradients of total sodium concentration (TSC) and R
STATISTICAL TEST
METHODS
Analyses of variance and mixed-effects models to estimate differences from time of day. Coefficients of variation to assess variability within and between participants. A P-value <0.05 was considered statistically significant.
RESULTS
RESULTS
The coefficients of variation varied from 5% to 18% for proton-based parametric sequences, while it was 38% for TSC over a day.
DATA CONCLUSION
CONCLUSIONS
Multiparametric MRI is stable over the day. The coefficients of variation over a day were lower for proton multiparametric MRI, but higher for sodium MRI.
EVIDENCE LEVEL
METHODS
2 TECHNICAL EFFICACY: Stage 2.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Karen Elise Jensens Fond
Organisme : Lundbeckfonden
ID : R272-2017-4023
Informations de copyright
© 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
Références
Copur S, Yavuz F, Sag AA, Tuttle KR, Kanbay M. Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression. Eur J Clin Invest 2022;52:e13765.
Leung G, Kirpalani A, Szeto SG, et al. Could MRI be used to image kidney fibrosis? A review of recent advances and remaining barriers. Clin J Am Soc Nephrol 2017;12:1019-1028.
Akbari A, Lemoine S, Salerno F, et al. Functional sodium MRI helps to measure corticomedullary sodium content in normal and diseased human kidneys. Radiology 2022;303:384-389.
Moon CH, Furlan A, Kim J-H, Zhao T, Shapiro R, Bae KT. Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (1H/23Na) coil: Initial experience. Eur Radiol 2014;24:1320-1326.
Mendichovszky I, Pullens P, Dekkers I, et al. Technical recommendations for clinical translation of renal MRI: A consensus project of the Cooperation in Science and Technology Action PARENCHIMA. Magn Reson Mater Phy 2020;33:131-140.
Emans TW, Janssen BJ, Joles JA, Krediet CTP. Circadian rhythm in kidney tissue oxygenation in the rat. Front Physiol 2017;8:205.
Hara M, Minami Y, Ohashi M, et al. Robust circadian clock oscillation and osmotic rhythms in inner medulla reflecting cortico-medullary osmotic gradient rhythm in rodent kidney. Sci Rep 2017;7:7306.
Eckerbom P, Hansell P, Cox E, et al. Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging. Am J Physiol Renal Physiol 2020;319:F966-F978.
Rankin AJ, Mayne K, Allwood-Spiers S, et al. Will advances in functional renal magnetic resonance imaging translate to the nephrology clinic? Nephrol Ther 2022;27:223-230.
Grist JT, Riemer F, Hansen E, et al. Visualization of sodium dynamics in the kidney by magnetic resonance imaging by a multisite study. Kidney Int 2020;98:1174-1178.
Dekkers IA, de Boer A, Sharma K, et al. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI. Magma 2020;33:163-176.
Bane O, Mendichovszky IA, Milani B, et al. Consensus-based technical recommendations for clinical translation of renal BOLD MRI. Magn Reson Mater Physiol 2020;33:199-215.
Ljimani A, Caroli A, Laustsen C, et al. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI. Magn Reson Mater Phy 2020;33:177-195.
Sacolick LI, Wiesinger F, Hancu I, Vogel MW. B1 mapping by Bloch-Siegert shift. Magn Reson Med 2010;63:1315-1322.
Nagel AM, Laun FB, Weber MA, Matthies C, Semmler W, Schad LR. Sodium MRI using a density-adapted 3D radial acquisition technique. Magn Reson Med 2009;62:1565-1573.
Vaeggemose M, Schulte RF, Laustsen C. Clinically feasible B1 field correction for multi-organ sodium imaging at 3 T. NMR Biomed 2022;36:e4835.
Grist JT, Hansen ESS, Zöllner FG, Laustsen C. Analysis protocol for renal sodium (23Na) MR imaging. Methods Mol Biol 2021;2216:689-696.
Milani B, Ansaloni A, Sousa-Guimaraes S, et al. Reduction of cortical oxygenation in chronic kidney disease: Evidence obtained with a new analysis method of blood oxygenation level-dependent magnetic resonance imaging. Nephrol Dial Transplant 2017;32:2097-2105.
Stachenfeld NS, DiPietro L, Palter SF, Nadel ER. Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. Am J Physiol 1998;274:R187-R195.
Stachenfeld NS, Taylor HS. Effects of estrogen and progesterone administration on extracellular fluid. J Appl Physiol 1985;2004(96):1011-1018.
de Boer A, Harteveld AA, Stemkens B, et al. Multiparametric renal MRI: An intrasubject test-retest repeatability study. J Magn Reson Imaging 2021;53:859-873.
Aronhime S, Calcagno C, Jajamovich GH, et al. DCE-MRI of the liver: Effect of linear and nonlinear conversions on hepatic perfusion quantification and reproducibility. J Magn Reson Imaging 2014;40:90-98.
Haneder S, Konstandin S, Morelli JN, et al. Quantitative and qualitative 23Na MR imaging of the human kidneys at 3 T: Before and after a water load. Radiology 2011;260:857-865.
Rasmussen CW, Bøgh N, Bech SK, et al. Fibrosis imaging with multiparametric proton and sodium MRI in pig injury models. NMR Biomed 2022;36:e4838.
Maril N, Margalit R, Rosen S, Heyman SN, Degani H. Detection of evolving acute tubular necrosis with renal 23Na MRI: Studies in rats. Kidney Int 2006;69:765-768.
James JR, Panda A, Lin C, Dydak U, Dale BM, Bansal N. In vivo sodium MR imaging of the abdomen at 3T. Abdom Imaging 2015;40:2272-2280.
Kaggie JD, Lanz T, McLean MA, et al. Combined 23 Na and 13 C imaging at 3.0 Tesla using a single-tuned large FOV birdcage coil. Magn Reson Med 2021;86:1734-1745.
Niesporek SC, Hoffmann SH, Berger MC, et al. Partial volume correction for in vivo (23)Na-MRI data of the human brain. Neuroimage 2015;112:353-363.
Zhao Y, Guo R, Li Y, Thulborn KR, Liang Z-P. High-resolution sodium imaging using anatomical and sparsity constraints for denoising and recovery of novel features. Magn Reson Med 2021;86:625-636.
Lachner S, Ruck L, Niesporek SC, et al. Comparison of optimized intensity correction methods for 23Na MRI of the human brain using a 32-channel phased array coil at 7 Tesla. Z Med Phys 2020;30:104-115.