Distinct subsets of anti-pulmonary autoantibodies correlate with disease severity and survival in severe COVID-19 patients.

Autoantibody Clinical outcome IgG IgM Lung Mortality Multi-producer Post-COVID SARS-CoV-2 Severe COVID-19

Journal

GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284

Informations de publication

Date de publication:
01 Sep 2023
Historique:
received: 25 04 2023
accepted: 24 07 2023
medline: 1 9 2023
pubmed: 1 9 2023
entrez: 1 9 2023
Statut: aheadofprint

Résumé

Autoantibodies targeting the lung tissue were identified in severe COVID-19 patients in this retrospective study. Fifty-three percent of 104 patients developed anti-pulmonary antibodies, the majority of which were IgM class, suggesting that they developed upon infection with SARS-CoV-2. Anti-pulmonary antibodies correlated with worse pulmonary function and a higher risk of multiorgan failure that was further aggravated if 3 or more autoantibody clones were simultaneously present (multi-producers). Multi-producer patients were older than the patients with less or no autoantibodies. One of the identified autoantibodies (targeting a pulmonary protein of ~ 50 kDa) associated with worse clinical outcomes, including mortality. In summary, severe COVID-19 is associated with the development of lung-specific autoantibodies, which may worsen the clinical outcome. Tissue proteome-wide tests, such as the ones applied here, can be used to detect autoimmunity in the post-COVID state to identify the cause of symptoms and to reveal a new target for treatment.

Identifiants

pubmed: 37656328
doi: 10.1007/s11357-023-00887-2
pii: 10.1007/s11357-023-00887-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Hungarian Academy of Sciences
ID : POST-COVID2021-16
Organisme : Hungarian Academy of Sciences
ID : POST-COVID2021-33
Organisme : Magyar Tudományos Akadémia
ID : NKM2022-30
Organisme : Hungarian Scientific Research Fund
ID : FK135327
Organisme : Hungarian Scientific Research Fund
ID : K142141
Organisme : Hungarian Scientific Research Fund
ID : K132623
Organisme : National Research, Development and Innovation Office
ID : TKP2021-EGA-19
Organisme : National Research, Development and Innovation Office
ID : TKP2021-EGA-20
Organisme : National Research, Development and Innovation Office
ID : TKP2020-NKA-04
Organisme : NKFIH
ID : K147243

Informations de copyright

© 2023. The Author(s).

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Auteurs

Emese Tóth (E)

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032, Debrecen, Hungary.
Center of Excellence, The Hungarian Academy of Sciences, Budapest, Hungary.

Miklós Fagyas (M)

Division of Cardiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Béla Nagy (B)

Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Ivetta Mányiné Siket (IM)

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Blanka Szőke (B)

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Lilla Mártha (L)

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Mohamed Mahdi (M)

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Gábor Erdősi (G)

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Zsófia Pólik (Z)

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

János Kappelmayer (J)

Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Zoltán Papp (Z)

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
ELKH-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Budapest, Hungary.
Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4032, Debrecen, Hungary.

Attila Borbély (A)

Division of Cardiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Tamás Szabó (T)

Department of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

József Balla (J)

ELKH-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Budapest, Hungary.
Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

György Balla (G)

ELKH-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Budapest, Hungary.
Department of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Attila Bácsi (A)

Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Zoltán Szekanecz (Z)

Department of Rheumatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Péter Bai (P)

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032, Debrecen, Hungary. baip@med.unideb.hu.
Center of Excellence, The Hungarian Academy of Sciences, Budapest, Hungary. baip@med.unideb.hu.
Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4032, Debrecen, Hungary. baip@med.unideb.hu.
MTA-DE Cell Biology and Signaling Research Group ELKH, Debrecen, 4032, Hungary. baip@med.unideb.hu.
MTA-DE Lendület Laboratory of Cellular Metabolism, 4032, Debrecen, Hungary. baip@med.unideb.hu.

Attila Tóth (A)

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. atitoth@med.unideb.hu.
ELKH-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Budapest, Hungary. atitoth@med.unideb.hu.
Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4032, Debrecen, Hungary. atitoth@med.unideb.hu.

Classifications MeSH