Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa.

Humans Retinal Cone Photoreceptor Cells / metabolism Transcriptome / genetics Reactive Oxygen Species / metabolism Retina / metabolism Retinitis Pigmentosa / pathology
CP: Neuroscience cone metabolism glucose transport lactate metabolism photoreceptor metabolic and epigenetic transcriptomes retinitis pigmentosa rod metabolism single cell RNA sequencing

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
26 09 2023
Historique:
received: 08 05 2023
revised: 21 06 2023
accepted: 15 08 2023
medline: 5 10 2023
pubmed: 1 9 2023
entrez: 1 9 2023
Statut: ppublish

Résumé

Most mutations in retinitis pigmentosa (RP) arise in rod photoreceptors, but cone photoreceptors, responsible for high-resolution daylight and color vision, are subsequently affected, causing the most debilitating features of the disease. We used mass spectroscopy to follow

Identifiants

DOI: 10.1016/j.celrep.2023.113054 PMID: 37656622 PMC: PMC10591869
pubmed: 37656622
pii: S2211-1247(23)01065-3
doi: 10.1016/j.celrep.2023.113054
pmc: PMC10591869
mid: NIHMS1932715
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113054

Subventions

Organisme : NEI NIH HHS
ID : R01 EY030933
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY034364
Pays : United States
Organisme : NEI NIH HHS
ID : U01 EY034591
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031324
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026158
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY032462
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Sang Joon Lee (SJ)

Department of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA; Department of Ophthalmology, Kosin University College of Medicine, #262 Gamcheon-ro, Seo-gu, Busan 49267, Korea.

Douglas Emery (D)

Department of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Eric Vukmanic (E)

Department of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Yekai Wang (Y)

Departments of Ophthalmology and Visual Sciences and Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.

Xiaoqin Lu (X)

Department of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Wei Wang (W)

Department of Ophthalmology and Visual Sciences, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Enzo Fortuny (E)

Department of Neurosurgery, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Robert James (R)

Department of Neurosurgery, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Henry J Kaplan (HJ)

Department of Ophthalmology, St. Louis University School of Medicine, St. Louis MO 63110, USA.

Yongqing Liu (Y)

Department of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.

Jianhai Du (J)

Departments of Ophthalmology and Visual Sciences and Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA. Electronic address: jianhai.du@hsc.wvu.edu.

Douglas C Dean (DC)

Department of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA. Electronic address: douglas.dean@louisville.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolic transcriptomics dictate responses of...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Cellules photoréceptrices › Cellules photoréceptrices de vertébré › Cellules photoréceptrices en cône de la rétine › Metabolic transcriptomics dictate responses of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Metabolic transcriptomics dictate responses of...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Metabolic transcriptomics dictate responses of...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Metabolic transcriptomics dictate responses of...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies héréditaires de l'oeil › Rétinite pigmentaire › Metabolic transcriptomics dictate responses of...