A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
22
12
2022
accepted:
15
08
2023
revised:
14
09
2023
medline:
18
9
2023
pubmed:
1
9
2023
entrez:
1
9
2023
Statut:
epublish
Résumé
Mean-field (MF) models are computational formalism used to summarize in a few statistical parameters the salient biophysical properties of an inter-wired neuronal network. Their formalism normally incorporates different types of neurons and synapses along with their topological organization. MFs are crucial to efficiently implement the computational modules of large-scale models of brain function, maintaining the specificity of local cortical microcircuits. While MFs have been generated for the isocortex, they are still missing for other parts of the brain. Here we have designed and simulated a multi-layer MF of the cerebellar microcircuit (including Granule Cells, Golgi Cells, Molecular Layer Interneurons, and Purkinje Cells) and validated it against experimental data and the corresponding spiking neural network (SNN) microcircuit model. The cerebellar MF was built using a system of equations, where properties of neuronal populations and topological parameters are embedded in inter-dependent transfer functions. The model time constant was optimised using local field potentials recorded experimentally from acute mouse cerebellar slices as a template. The MF reproduced the average dynamics of different neuronal populations in response to various input patterns and predicted the modulation of the Purkinje Cells firing depending on cortical plasticity, which drives learning in associative tasks, and the level of feedforward inhibition. The cerebellar MF provides a computationally efficient tool for future investigations of the causal relationship between microscopic neuronal properties and ensemble brain activity in virtual brain models addressing both physiological and pathological conditions.
Identifiants
pubmed: 37656758
doi: 10.1371/journal.pcbi.1011434
pii: PCOMPBIOL-D-22-01885
pmc: PMC10501640
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1011434Informations de copyright
Copyright: © 2023 Lorenzi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
I have read the journal’s policy and the authors of this manuscript have the following competing interests: CGWK is a shareholder in Queen Square Analytics Ltd.
Références
Cells. 2022 Mar 19;11(6):
pubmed: 35326498
Front Cell Neurosci. 2019 Feb 11;13:21
pubmed: 30853896
Neuroimage. 2017 Oct 1;159:388-402
pubmed: 28782678
Cereb Cortex. 2015 Nov;25(11):4273-83
pubmed: 25596591
PLoS Comput Biol. 2020 Dec 30;16(12):e1007937
pubmed: 33378395
Neuroimage. 2018 Nov 1;181:818-830
pubmed: 30130648
Front Syst Neurosci. 2022 Jun 16;16:919761
pubmed: 35782305
Front Cell Neurosci. 2018 Oct 01;12:331
pubmed: 30327590
J Neurosci. 2007 Feb 7;27(6):1285-96
pubmed: 17287503
PLoS Comput Biol. 2022 Oct 4;18(10):e1010564
pubmed: 36194625
Front Comput Neurosci. 2013 May 28;7:57
pubmed: 23755005
Neuroimage. 2019 Oct 1;199:730-744
pubmed: 28219774
eNeuro. 2020 Mar 24;7(2):
pubmed: 32066612
J Neurosci. 2013 Apr 10;33(15):6552-6
pubmed: 23575852
Cereb Cortex. 1997 Apr-May;7(3):237-52
pubmed: 9143444
Nat Commun. 2019 Jun 6;10(1):2478
pubmed: 31171779
J Theor Biol. 1998 Nov 7;195(1):87-95
pubmed: 9802952
Front Neuroinform. 2021 Apr 22;15:659005
pubmed: 33967731
Front Cell Neurosci. 2007 Dec 30;1:2
pubmed: 18946520
Nat Neurosci. 2009 Aug;12(8):1042-9
pubmed: 19578381
J Neurosci. 2006 Jan 25;26(4):1314-28
pubmed: 16436619
Brain. 2013 Mar;136(Pt 3):696-709
pubmed: 23404337
Front Neuroinform. 2018 Dec 03;12:88
pubmed: 30559658
Trends Neurosci. 2022 Oct;45(10):777-790
pubmed: 35906100
Front Neuroinform. 2019 May 15;13:37
pubmed: 31156416
Mov Disord. 2021 Dec;36(12):2767
pubmed: 34755914
Nature. 2015 Oct 15;526(7573):439-42
pubmed: 26469054
Sci Rep. 2016 Jan 07;6:18854
pubmed: 26740369
PLoS Comput Biol. 2020 Apr 23;16(4):e1007822
pubmed: 32324734
J Integr Neurosci. 2011 Sep;10(3):317-52
pubmed: 21960306
Neuroimage. 2012 Jan 16;59(2):1261-74
pubmed: 21924363
J Neurosci. 2009 Aug 19;29(33):10309-20
pubmed: 19692605
J Neural Eng. 2022 Apr 07;19(2):
pubmed: 35320783
Cereb Cortex. 2019 Mar 1;29(3):1351-1368
pubmed: 30615116
Front Comput Neurosci. 2019 Oct 01;13:68
pubmed: 31632258
Neuroimage. 2003 Aug;19(4):1273-302
pubmed: 12948688
Cerebellum. 2021 Oct;20(5):678-686
pubmed: 31965455
CNS Neurosci Ther. 2020 Feb;26(2):207-214
pubmed: 31730272
J Theor Biol. 2009 Apr 21;257(4):642-63
pubmed: 19168074
Neuroimage. 2015 Jul 1;114:88-104
pubmed: 25862265
Neural Comput. 2008 Jan;20(1):1-43
pubmed: 18044999
PLoS Comput Biol. 2008 Aug 29;4(8):e1000092
pubmed: 18769680
J Physiol. 1998 Aug 1;510 ( Pt 3):845-66
pubmed: 9660898
Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2118954119
pubmed: 35349338
Biol Cybern. 1995 Sep;73(4):357-66
pubmed: 7578475
Neuroimage. 2022 May 1;251:118985
pubmed: 35149228
J Neurosci. 2009 Jan 14;29(2):381-92
pubmed: 19144838
Neuron. 2019 Mar 20;101(6):1042-1056
pubmed: 30897356
Clinics (Sao Paulo). 2011;66 Suppl 1:3-17
pubmed: 21779718
J Neurosci. 2001 Feb 1;21(3):759-70
pubmed: 11157062
Brain Res Rev. 2011 Jan 7;66(1-2):220-45
pubmed: 20937306
Neuroimage. 2015 Aug 15;117:343-57
pubmed: 25837600
J Physiol. 2016 Jul 1;594(13):3791-808
pubmed: 27146816
Front Comput Neurosci. 2015 Feb 25;9:24
pubmed: 25762922
Neuroimage. 2006 Dec;33(4):1227-31
pubmed: 17023183
Front Neurosci. 2020 Nov 27;14:593867
pubmed: 33328865
Neural Comput. 2009 Jan;21(1):46-100
pubmed: 19210171
J Neurosci. 2004 Mar 10;24(10):2345-56
pubmed: 15014109
Front Cell Neurosci. 2017 Sep 13;11:278
pubmed: 28955206
J Neurophysiol. 2018 Dec 1;120(6):2707-2709
pubmed: 30110238
J Neurophysiol. 1999 Jan;81(1):277-87
pubmed: 9914288
Neural Netw. 2021 Nov;143:183-197
pubmed: 34157643
Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S152-5
pubmed: 20082979
J Neurosci. 2011 Jun 22;31(25):9070-4
pubmed: 21697357
Neural Netw. 2013 Nov;47:103-11
pubmed: 23434303
Neuroimage. 2020 Jul 15;215:116817
pubmed: 32278092
Biophys J. 1972 Jan;12(1):1-24
pubmed: 4332108
Neuroimage. 2008 Jan 1;39(1):269-78
pubmed: 17936017
IEEE Trans Neural Netw Learn Syst. 2017 Nov.;28(11):2748-2762
pubmed: 27608482
Entropy (Basel). 2020 May 14;22(5):
pubmed: 33286324
Front Cell Neurosci. 2020 Jul 31;14:240
pubmed: 32848628
Front Cell Neurosci. 2015 Feb 24;9:47
pubmed: 25759640
Neuron. 2012 Nov 21;76(4):695-711
pubmed: 23177956
Arq Neuropsiquiatr. 2019 Mar;77(3):184-193
pubmed: 30970132
PLoS Comput Biol. 2011 Aug;7(8):e1002124
pubmed: 21852943
Front Neuroinform. 2013 Jun 11;7:10
pubmed: 23781198
Front Neural Circuits. 2013 Jan 10;6:116
pubmed: 23335884
Handb Clin Neurol. 2018;155:61-72
pubmed: 29891077
Neurol Clin. 2014 Nov;32(4):957-77
pubmed: 25439291
Neural Comput. 2019 Apr;31(4):653-680
pubmed: 30764741
Nat Neurosci. 2020 Sep;23(9):1102-1110
pubmed: 32661395
Science. 2013 Jun 21;340(6139):1472-5
pubmed: 23788795
Neuroscience. 2021 May 10;462:22-35
pubmed: 33075461
Elife. 2015 Jun 17;4:
pubmed: 26083712
J Math Neurosci. 2020 May 27;10(1):9
pubmed: 32462281
Continuum (Minneap Minn). 2022 Oct 01;28(5):1409-1434
pubmed: 36222772
Sci Rep. 2021 Sep 2;11(1):17611
pubmed: 34475456
Neurobiol Aging. 2017 Jan;49:20-30
pubmed: 27728831
PLoS Comput Biol. 2017 Apr 19;13(4):e1005507
pubmed: 28422957
Brain Struct Funct. 2015 Nov;220(6):3369-84
pubmed: 25134682
J Physiol. 2005 Sep 15;567(Pt 3):829-50
pubmed: 16002452
Commun Biol. 2020 May 8;3(1):222
pubmed: 32385389
Commun Biol. 2020 Oct 30;3(1):635
pubmed: 33128000
Life (Basel). 2021 Jul 31;11(8):
pubmed: 34440520
Exp Neurol. 2022 Aug;354:114111
pubmed: 35569510
Sci Rep. 2021 Feb 16;11(1):3873
pubmed: 33594118
J Neurosci. 2007 May 23;27(21):5559-70
pubmed: 17522301
Cell Rep. 2015 Dec 1;13(9):1977-88
pubmed: 26655909
Front Neurosci. 2014 Jul 30;8:223
pubmed: 25126054
Commun Biol. 2022 Nov 14;5(1):1240
pubmed: 36376444
Nat Commun. 2016 Dec 15;7:13722
pubmed: 27976716
J Neurophysiol. 2020 Mar 1;123(3):1042-1051
pubmed: 31851573
Front Syst Neurosci. 2019 Dec 06;13:75
pubmed: 31866837
Biomedicines. 2023 May 18;11(5):
pubmed: 37239146
Trends Neurosci. 2009 Jan;32(1):30-40
pubmed: 18977038
Elife. 2018 Dec 18;7:
pubmed: 30561331
Neurosci Behav Physiol. 2004 Jul;34(6):633-8
pubmed: 15368913
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5555-60
pubmed: 16567615
J Neurophysiol. 2005 Nov;94(5):3637-42
pubmed: 16014787
Netw Neurosci. 2021 Aug 30;5(3):757-782
pubmed: 34746626
PLoS One. 2013 May 31;8(5):e64828
pubmed: 23741401
eNeuro. 2022 Mar 11;9(2):
pubmed: 35217544
Front Comput Neurosci. 2019 Jun 06;13:35
pubmed: 31244635
Neurology. 2022 Mar 08;98(10):e1077-e1089
pubmed: 35058336
Front Aging Neurosci. 2022 Aug 05;14:868342
pubmed: 35992607
J Neurosci. 2014 Jun 4;34(23):7886-98
pubmed: 24899711
J Comput Neurosci. 2018 Feb;44(1):45-61
pubmed: 29139050
Front Comput Neurosci. 2014 Dec 01;8:157
pubmed: 25520646