BRAF

Humans Dimerization Proto-Oncogene Proteins B-raf / genetics HSP90 Heat-Shock Proteins Amino Acids

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
09 2023
Historique:
medline: 4 9 2023
pubmed: 1 9 2023
entrez: 1 9 2023
Statut: ppublish

Résumé

In-frame

Identifiants

DOI: 10.1126/sciadv.ade7486 PMID: 37656784
pubmed: 37656784
doi: 10.1126/sciadv.ade7486
doi:

Substances chimiques

naporafenib 15JL80DG6H
Proto-Oncogene Proteins B-raf EC 2.7.11.1
HSP90 Heat-Shock Proteins 0
Amino Acids 0
BRAF protein, human EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eade7486

Auteurs

Manuel Lauinger (M)

Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Faculty of Biology, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0001-5359-527X

Daniel Christen (D)

Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Faculty of Biology, University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Rhena F U Klar (RFU)

Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Faculty of Biology, University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Freeze-O Organoid Bank, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Internal Medicine I (Hematology, Oncology, and Stem Cell Transplantation), University Hospital of Freiburg, Freiburg, Germany.
Institute of Medical Bioinformatics and Systems Medicine (IBSM), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0003-3264-8170

Carole Roubaty (C)

Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
ORCID: 0000-0003-1658-8972

Christoph E Heilig (CE)

Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
ORCID: 0000-0001-8869-1421

Michael Stumpe (M)

Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
ORCID: 0000-0002-9443-9326

Jennifer J Knox (JJ)

PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Nikolina Radulovich (N)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
ORCID: 0000-0002-8224-7263

Laura Tamblyn (L)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Irene Y Xie (IY)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
ORCID: 0000-0002-4911-1364

Peter Horak (P)

Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
ORCID: 0000-0003-4536-9306

Andrea Forschner (A)

Department of Dermatology, University Hospital of Tübingen, Tübingen, Germany.
German Cancer Consortium (DKTK), DKFZ partner site Tübingen, Eberhard Karls University, Tübingen, Germany.
ORCID: 0000-0002-6185-4945

Michael Bitzer (M)

German Cancer Consortium (DKTK), DKFZ partner site Tübingen, Eberhard Karls University, Tübingen, Germany.
Center for Personalized Medicine Tübingen, Eberhard Karls University, Tübingen, Germany.
Department of Internal Medicine I, Eberhard-Karls University, Tübingen, Germany.
ORCID: 0000-0002-4463-8263

Uwe A Wittel (UA)

Department of General and Visceral Surgery, University of Freiburg Medical Center, Faculty of Medicine, 79106 Freiburg, Germany.
ORCID: 0000-0001-6194-2374

Melanie Boerries (M)

German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Institute of Medical Bioinformatics and Systems Medicine (IBSM), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Comprehensive Cancer Center Freiburg (CCCF), Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
ORCID: 0000-0002-3670-0602

Claudia R Ball (CR)

Department for Translational Medical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium (DKTK), Dresden, Germany.
Technische Universität Dresden, Faculty of Biology, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0002-1749-3791

Christoph Heining (C)

Department for Translational Medical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium (DKTK), Dresden, Germany.
ORCID: 0000-0002-1256-8387

Hanno Glimm (H)

Department for Translational Medical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Cancer Consortium (DKTK), Dresden, Germany.
Translational Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0003-4104-1135

Martina Fröhlich (M)

Computational Oncology Group, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Daniel Hübschmann (D)

German Cancer Consortium (DKTK), Heidelberg, Germany.
Computational Oncology Group, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pattern Recognition and Digital Medicine Group, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.
ORCID: 0000-0002-6041-7049

Steven Gallinger (S)

PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Ralph Fritsch (R)

Department of Internal Medicine I (Hematology, Oncology, and Stem Cell Transplantation), University Hospital of Freiburg, Freiburg, Germany.
Department of Medical Oncology and Haematology, University Hospital of Zurich, Zurich, Switzerland.

Stefan Fröhling (S)

Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
ORCID: 0000-0001-7907-4595

Grainne M O'Kane (GM)

PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
ORCID: 0000-0002-8690-403X

Jörn Dengjel (J)

Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
ORCID: 0000-0002-9453-4614

Tilman Brummer (T)

Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Freeze-O Organoid Bank, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Comprehensive Cancer Center Freiburg (CCCF), Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Center for Biological Signalling Studies BIOSS, University of Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0003-4387-7905

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › BRAF
questionsmedicales.fr › Métabolisme › Dimérisation › BRAF
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › BRAF
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Protéines du choc thermique › Protéines du choc thermique HSP90 › BRAF
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › BRAF