Haunting innate immune memories of COVID-19.

Humans COVID-19 / genetics Epigenomics Hematopoietic Stem Cells Post-Acute COVID-19 Syndrome / immunology SARS-CoV-2 Trained Immunity Inflammation / pathology

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
31 08 2023
Historique:
received: 24 07 2023
revised: 26 07 2023
accepted: 27 07 2023
medline: 4 9 2023
pubmed: 2 9 2023
entrez: 1 9 2023
Statut: ppublish

Résumé

In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections via IL-6 induce persistent epigenetic signatures in hemopoietic stem cells and their myeloid progenitors associated with increased inflammatory potential.

Identifiants

DOI: 10.1016/j.cell.2023.07.033 PMID: 37657416
pubmed: 37657416
pii: S0092-8674(23)00848-6
doi: 10.1016/j.cell.2023.07.033
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

3753-3755

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Birgit Sawitzki (B)

Translational Immunology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: birgit.sawitzki@bih-charite.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Haunting innate immune memories of COVID-19.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Haunting innate immune memories of COVID-19.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Haunting innate immune memories of COVID-19.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Haunting innate immune memories of COVID-19.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Troubles post-infectieux › Syndrome de post-COVID-19 › Haunting innate immune memories of COVID-19.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Haunting innate immune memories of COVID-19.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Immunité entraînée › Haunting innate immune memories of COVID-19.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Haunting innate immune memories of COVID-19.