NAD
Nitric oxide
Reactive oxygen species
SARS-CoV-2
Journal
Nitric oxide : biology and chemistry
ISSN: 1089-8611
Titre abrégé: Nitric Oxide
Pays: United States
ID NLM: 9709307
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
received:
28
04
2023
revised:
10
08
2023
accepted:
30
08
2023
medline:
14
11
2023
pubmed:
2
9
2023
entrez:
1
9
2023
Statut:
ppublish
Résumé
SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), induces vascular endothelial dysfunction, but the mechanisms are unknown. We tested the hypothesis that the "circulating milieu" (plasma) of patients with COVID-19 would cause endothelial cell dysfunction (characterized by lower nitric oxide (NO) production), which would be linked to greater reactive oxygen species (ROS) bioactivity and depletion of the critical metabolic co-substrate, nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 37657532
pii: S1089-8603(23)00072-1
doi: 10.1016/j.niox.2023.08.003
pii:
doi:
Substances chimiques
NAD
0U46U6E8UK
Reactive Oxygen Species
0
Nitric Oxide
31C4KY9ESH
Nicotinamide Mononucleotide
1094-61-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no competing interests to declare.