Novel alkyl-substituted 4-methoxy benzaldehyde thiosemicarbazones: Multi-target directed ligands for the treatment of Alzheimer's disease.

Humans Alzheimer Disease / drug therapy Thiosemicarbazones / pharmacology Ligands Acetylcholinesterase Benzaldehydes Nitrites Neuroblastoma
Alzheimer's disease Cholinesterase N-methyl-D-aspartate Thiosemicarbazone

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
15 Oct 2023
Historique:
received: 28 01 2023
revised: 14 08 2023
accepted: 25 08 2023
medline: 22 9 2023
pubmed: 2 9 2023
entrez: 1 9 2023
Statut: ppublish

Résumé

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting mental ability and interrupts neurocognitive functions. Treating multifactorial conditions of AD with a single-target-directed drug is highly difficult. Thus, a multi-target-directed ligand (MTDL) development strategy has been developed as a promising approach for the treatment of AD. Herein, we have synthesized two novel thiosemicarbazones as MTDLs and reported their bioactivities against diverse neuropathological events involved in AD. In vitro studies revealed that both compounds exhibited promising anticholinesterase activity (AChE, IC

Identifiants

DOI: 10.1016/j.ejphar.2023.176028 PMID: 37657740
pubmed: 37657740
pii: S0014-2999(23)00540-X
doi: 10.1016/j.ejphar.2023.176028
pii:
doi:

Substances chimiques

Thiosemicarbazones 0
Ligands 0
Acetylcholinesterase EC 3.1.1.7
4-anisaldehyde 9PA5V6656V
Benzaldehydes 0
Nitrites 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

176028

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Mokshada Varma (M)

Bioprospecting Group, Agharkar Research Institute, Savitribai Phule Pune University, G. G. Agharkar Road, Pune, Maharashtra, 411004, India.

Vinod Ugale (V)

Bioprospecting Group, Agharkar Research Institute, Savitribai Phule Pune University, G. G. Agharkar Road, Pune, Maharashtra, 411004, India; Department of Biochemistry I - Receptor Biochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany; Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, 425405, India. Electronic address: vinod.ugale@rediffmail.com.

Javeria Shaukat (J)

Department of Biochemistry I - Receptor Biochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.

Michael Hollmann (M)

Department of Biochemistry I - Receptor Biochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.

Padmaja Shete (P)

Bioprospecting Group, Agharkar Research Institute, Savitribai Phule Pune University, G. G. Agharkar Road, Pune, Maharashtra, 411004, India.

Bhupendra Shravage (B)

Developmental Biology Group, Agharkar Research Institute, Savitribai Phule Pune University, Pune, Maharashtra, 411004, India.

Sakharam Tayade (S)

Department of Chemistry, Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.

Avinash Kumbhar (A)

Department of Chemistry, Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.

Ray Butcher (R)

Department of Chemistry, Howard University, Washington, DC, 20059, USA.

Vinod Jani (V)

HPC Medical & Bioinformatics Applications Group, Centre for Development of Advanced Computing (C-DAC), Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.

Uddhavesh Sonavane (U)

HPC Medical & Bioinformatics Applications Group, Centre for Development of Advanced Computing (C-DAC), Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.

Rajendra Joshi (R)

HPC Medical & Bioinformatics Applications Group, Centre for Development of Advanced Computing (C-DAC), Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.

Deepak Lokwani (D)

Rajashri Shahu College of Pharmacy, Buldana, Maharashtra, India.

Prasad Kulkarni (P)

Bioprospecting Group, Agharkar Research Institute, Savitribai Phule Pune University, G. G. Agharkar Road, Pune, Maharashtra, 411004, India. Electronic address: kulkarniari@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel alkyl-substituted 4-methoxy benzaldehyde...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Novel alkyl-substituted 4-methoxy benzaldehyde...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiosemicarbazones › Novel alkyl-substituted 4-methoxy benzaldehyde...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Novel alkyl-substituted 4-methoxy benzaldehyde...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Novel alkyl-substituted 4-methoxy benzaldehyde...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Benzaldéhydes › Novel alkyl-substituted 4-methoxy benzaldehyde...
questionsmedicales.fr › Composés chimiques organiques › Nitrites › Novel alkyl-substituted 4-methoxy benzaldehyde...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › Novel alkyl-substituted 4-methoxy benzaldehyde...