Transcription-coupled nucleosome assembly.
FACT
Spt6
cryptic transcription
histone chaperones
histone exchange
nucleosome recycling
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
12
05
2023
revised:
21
07
2023
accepted:
04
08
2023
pubmed:
2
9
2023
medline:
2
9
2023
entrez:
1
9
2023
Statut:
ppublish
Résumé
Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the active site. However, in most transcribed genes, nucleosomes remain intact due to transcription-coupled chromatin assembly mechanisms. These mechanisms primarily involve the local reassembly of displaced nucleosomes to prevent (epi)genomic instability and the emergence of cryptic transcription. As a fail-safe mechanism, cells can assemble nucleosomes de novo, particularly in highly transcribed genes, but this may result in the loss of epigenetic information. This review examines transcription-coupled chromatin assembly, with an emphasis on studies in yeast and recent structural studies. These studies shed light on how elongation factors and histone chaperones coordinate to enable nucleosome recycling during transcription.
Identifiants
pubmed: 37657993
pii: S0968-0004(23)00206-2
doi: 10.1016/j.tibs.2023.08.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
978-992Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declared no conflict of interest.