Outcomes up to age 36 months after congenital Zika virus infection-U.S. states.

Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
01 Sep 2023
Historique:
received: 23 11 2022
accepted: 15 06 2023
revised: 24 05 2023
pubmed: 2 9 2023
medline: 2 9 2023
entrez: 1 9 2023
Statut: aheadofprint

Résumé

To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure. From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥1 follow-up exam after 14 days of age or with ≥1 visit with development reported, respectively. Among 2248 infants, 10.1% were born preterm, and 10.5% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1881 children ≥1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay. Understanding the prevalence of developmental delays and healthcare needs of children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families. We characterize pregnancy and infant outcomes and describe neurodevelopmental abnormalities up to 36 months of age by presence of Zika associated birth defects (ZBD). Neurologic sequelae and developmental delays were common among children with ZBD. Children with ZBD had increased frequency of neurologic sequelae and developmental delay compared to children without ZBD. Longitudinal follow-up of infants with Zika virus exposure in utero is important to characterize neurodevelopmental delay not apparent in early infancy, but logistically challenging in surveillance models.

Sections du résumé

BACKGROUND BACKGROUND
To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure.
METHODS METHODS
From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥1 follow-up exam after 14 days of age or with ≥1 visit with development reported, respectively.
RESULTS RESULTS
Among 2248 infants, 10.1% were born preterm, and 10.5% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1881 children ≥1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay.
CONCLUSION CONCLUSIONS
Understanding the prevalence of developmental delays and healthcare needs of children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families.
IMPACT CONCLUSIONS
We characterize pregnancy and infant outcomes and describe neurodevelopmental abnormalities up to 36 months of age by presence of Zika associated birth defects (ZBD). Neurologic sequelae and developmental delays were common among children with ZBD. Children with ZBD had increased frequency of neurologic sequelae and developmental delay compared to children without ZBD. Longitudinal follow-up of infants with Zika virus exposure in utero is important to characterize neurodevelopmental delay not apparent in early infancy, but logistically challenging in surveillance models.

Identifiants

DOI: 10.1038/s41390-023-02787-9 PMID: 37658124
pubmed: 37658124
doi: 10.1038/s41390-023-02787-9
pii: 10.1038/s41390-023-02787-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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Auteurs

Varsha Neelam (V)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA. pju4@cdc.gov.
ORCID: 0000-0001-9900-3567

Kate R Woodworth (KR)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Daniel J Chang (DJ)

Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.

Nicole M Roth (NM)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Megan R Reynolds (MR)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Amanda Akosa (A)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Christopher P Carr (CP)

Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.

Kayla N Anderson (KN)

Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Sarah B Mulkey (SB)

Children's National Hospital, Washington, D. C., USA.
The George Washington University School of Medicine and Health Sciences, Washington, D. C., USA.

Roberta L DeBiasi (RL)

Children's National Hospital, Washington, D. C., USA.
The George Washington University School of Medicine and Health Sciences, Washington, D. C., USA.

Cara Biddle (C)

Children's National Hospital, Washington, D. C., USA.
The George Washington University School of Medicine and Health Sciences, Washington, D. C., USA.

Ellen H Lee (EH)

New York City Department of Health & Mental Hygiene, New York City, NY, USA.

Amanda L Elmore (AL)

Florida Department of Health, Tampa, FL, USA.

Sarah J Scotland (SJ)

Massachusetts Department of Public Health, Boston, MA, USA.

Similoluwa Sowunmi (S)

California Department of Public Health, Sacramento, CA, USA.

Nicole D Longcore (ND)

New York State Department of Health, Albany, NY, USA.

Muhammad Ahmed (M)

New Jersey Department of Health, Trenton, NJ, USA.

Peter H Langlois (PH)

Texas Department of State Health Services, Austin, TX, USA.

Salma Khuwaja (S)

Houston Health Department, Houston, TX, USA.

Shea Elizabeth Browne (SE)

Virginia Department of Health, Richmond, VA, USA.

Leah Lind (L)

Pennsylvania Department of Health, Pittsburgh, PA, USA.

Kyoo Shim (K)

Dallas County Health and Human Services, Dallas, TX, USA.

Michael Gosciminski (M)

Rhode Island Department of Health, Providence, RI, USA.

Rachel Blumenfeld (R)

Philadelphia Department of Public Health, Philadelphia, PA, USA.

Shreya Khuntia (S)

District of Columbia Department of Health, Washington, D. C, USA.

Umme-Aiman Halai (UA)

Los Angeles County Department of Public Health, Los Angeles, CA, USA.

Autumn Locklear (A)

North Carolina Department of Health and Human Services, Chapel Hill, NC, USA.

Mary Chan (M)

Washington State Department of Health, Seattle, WA, USA.

Teri' Willabus (T)

Georgia Department of Public Health, Atlanta, GA, USA.

Julius Tonzel (J)

Louisiana Department of Health, New Orleans, LA, USA.

Natalie S Marzec (NS)

Colorado Department of Public Health and Environment, Denver, CO, USA.

Nianest Alers Barreto (NA)

Hawaii Department of Health, Honolulu, HI, USA.

Connie Sanchez (C)

Hidalgo County Health & Human Services Department, Hidalgo, TX, USA.

Jane Fornoff (J)

Illinois Department of Public Health, Springfield, IL, USA.

Shelby Hale (S)

Ohio Department of Health, Columbus, OH, USA.

Amy Nance (A)

Utah Department of Health and Human Services, Salt Lake City, UT, USA.

Lisa Iguchi (L)

Oregon Health Authority, Salem, OR, USA.

Sowmya N Adibhatla (SN)

Wisconsin Department of Health Services, Madison, WI, USA.

Emily Potts (E)

Indiana Department of Health, Indianapolis, IN, USA.

Elizabeth Schiffman (E)

Minnesota Department of Health, Minneapolis, MN, USA.

Devin Raman (D)

Southern Nevada Health District, Las Vegas, NV, USA.

Morgan F McDonald (MF)

Tennessee Department of Health, Nashville, TN, USA.

Brandi Stricklin (B)

Arkansas Department of Health, Little Rock, AR, USA.

Elizabeth Ludwig (E)

Nebraska Department of Health and Human Services, Lincoln, NE, USA.

Lindsay Denson (L)

Oklahoma State Department of Health, Oklahoma City, OK, USA.

Dianna Contreras (D)

Arizona Department of Health Services, Tempe, AZ, USA.

Paul A Romitti (PA)

University of Iowa College of Public Health, Iowa City, IA, USA.

Emily Ferrell (E)

Kentucky Department for Public Health, Georgetown, KY, USA.

Meghan Marx (M)

South Dakota Department of Health, Pierre, SD, USA.

Kimberly Signs (K)

Michigan Department of Health and Human Services, Lansing, MI, USA.

Amie Cook (A)

Kansas Department of Health and Environment, Topeka, KS, USA.

Vinita Oberoi Leedom (VO)

South Carolina Department of Health and Environmental Control, Florence, SC, USA.

Suzann Beauregard (S)

New Hampshire Department of Health and Human Services, Concord, NH, USA.

Lucia C Orantes (LC)

Vermont Department of Health, Burlington, VT, USA.

Laura Cronquist (L)

North Dakota Department of Health, Bismarck, ND, USA.

Lesley Roush (L)

West Virginia Bureau for Public Health, Charleston, WV, USA.

Shana Godfred-Cato (S)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Suzanne M Gilboa (SM)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Dana Meaney-Delman (D)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Margaret A Honein (MA)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Cynthia A Moore (CA)

Goldbelt Professional Services, LLC, Chesapeake, VA, USA.

Van T Tong (VT)

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Classifications MeSH