Relative ability of aqueous humor from dogs with and without primary angle-closure glaucoma and ADAMTS10 open-angle glaucoma to catalyze or inhibit collagenolysis.
canine
extracellular matrix
glaucoma
matrix metalloproteinases (MMP)
tissue inhibitors of metalloproteinases (TIMP)
Journal
Veterinary ophthalmology
ISSN: 1463-5224
Titre abrégé: Vet Ophthalmol
Pays: England
ID NLM: 100887377
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
revised:
23
07
2023
received:
21
06
2023
accepted:
16
08
2023
medline:
2
9
2023
pubmed:
2
9
2023
entrez:
1
9
2023
Statut:
aheadofprint
Résumé
The objective of the study was to compare the ability of aqueous humor (AH) from dogs with primary angle-closure glaucoma (CPACG), companion dogs without overt evidence of CPACG, and Beagles with and without ADAMTS10 open-angle glaucoma (ADAMTS10-OAG) to catalyze or inhibit collagenolysis. Seventeen normal pet dogs, 27 dogs with CPACG, 19 Beagles with ADAMTS10-OAG, and 4 unaffected Beagles. A fluorescein-based substrate degradation assay was used to assess AH proteolytic capacity. Samples were then assayed using the same substrate degradation assay, with recombinant activated matrix metalloproteinase-2 (MMP-2) added to measure protease inhibition effects. For the protease activity assay, relative fluorescence (RF) for AH from normal pet dogs was 13.28 ± 2.25% of control collagenase while RF for AH from dogs with CPACG was 17.47 ± 4.67%; RF was 8.57 ± 1.72% for ADAMTS10-OAG Beagles and 7.99 ± 1.15% for unaffected Beagles. For the MMP-2 inhibition assay, RF for AH from normal dogs was 34.96 ± 15.04% compared to MMP-2 controls, while RF from dogs with CPACG was 16.69 ± 7.95%; RF was 85.85 ± 13.23% for Beagles with ADAMTS10-OAG and 94.51 ± 8.36% for unaffected Beagles. Significant differences were found between dogs with CPACG and both normal pet dogs and dogs with ADAMTS10-OAG and between normal pet dogs and both groups of Beagles. AH from dogs with CPACG is significantly more able to catalyze proteolysis and inhibit MMP-2 than AH from normal dogs or dogs with ADAMTS10-OAG. Results suggest that pathogenesis may differ between CPACG and ADAMTS10-OAG.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY032478
Pays : United States
Organisme : NIH HHS
ID : R01-EY032478
Pays : United States
Organisme : NIH HHS
ID : R01-EY025752
Pays : United States
Informations de copyright
© 2023 American College of Veterinary Ophthalmologists.
Références
Plummer CE, Komáromy AM, Gelatt KN. The canine glaucomas. In: Gelatt KN, Ben-Shlomo G, Gilger BC, Hendrix DVH, Kern TJ, Plummer CE, eds. Veterinary Ophthalmology. 6th ed. John Wiley & Sons, Inc.; 2021:1173-1255.
Komáromy AM, Bras D, Esson DW, et al. The future of canine glaucoma. Vet Ophthalmol. 2019;22(5):726-740.
Kuchtey J, Kunkel J, Esson D, et al. Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles. Invest Ophthalmol Vis Sci. 2013;54(3):1881-1886.
Ahonen SJ, Kaukonen M, Nussdorfer FD, Harman CD, Komáromy AM, Lohi H. A novel missense mutation in ADAMTS10 in Norwegian Elkhound primary glaucoma. PloS One. 2014;9(11):e111941.
Forman OP, Pettitt L, Komaromy AM, et al. A novel genome-wide association study approach using genotyping by exome sequencing leads to the identification of a primary open angle glaucoma associated inversion disrupting ADAMTS17. PloS One. 2015;10(12):e0143546.
Oliver JA, Forman OP, Pettitt L, et al. Two independent mutations in ADAMTS17 are associated with primary open angle glaucoma in the Basset Hound and Basset Fauve de Bretagne breeds of dog. PloS One. 2015;10(10):e0140436.
Oliver JAC, Rustidge S, Pettitt L, et al. Evaluation of ADAMTS17 in Chinese Shar-Pei with primary open-angle glaucoma, primary lens luxation, or both. Am J Vet Res. 2018;79(1):98-106.
Yoshida K, Kawai M, Utsunomiya T, et al. Extracellular matrix gene expression in human trabecular meshwork cells following mechanical fluid flow stimulation. Int J Ophthalmol. 2022;15(3):388-393.
De Groef L, Van Hove I, Dekeyster E, et al. MMPs in the trabecular meshwork: promising targets for future glaucoma therapies? Invest Ophthalmol Vis Sci. 2013;54(12):7756-7763.
Acott TS, Kelley MJ, Keller KE, et al. Intraocular pressure homeostasis: maintaining balance in a high-pressure environment. J Ocul Pharmacol Ther. 2014;30(2-3):94-101.
Bradley JM, Kelley MJ, Zhu X, Anderssohn AM, Alexander JP, Acott TS. Effects of mechanical stretching on trabecular matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2001;42(7):1505-1513.
Vranka JA, Kelley MJ, Acott TS, Keller KE. Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma. Exp Eye Res. 2015;133:112-125.
Pouw AE, Greiner MA, Coussa RG, et al. Cell-matrix interactions in the eye: from cornea to choroid. Cell. 2021;10(3):687.
Van der Linde-Sipman JS. Dysplasia of the pectinate ligament and primary glaucoma in the Bouvier des Flandres dog. Vet Pathol. 1997;24(3):201-206.
Wood JL, Lakhani KH, Read RA. Pectinate ligament dysplasia and glaucoma in flat coated retrievers. II. Assessment of prevalence and heritability. Vet Ophthalmol. 1998;1(2-3):91-99.
Ekesten B, Narfström K. Correlation of morphologic features of the iridocorneal angle to intraocular pressure in Samoyeds. Am J Vet Res. 1991;52(11):1875-1878.
Bjerkås E, Ekesten B, Farstad W. Pectinate ligament dysplasia and narrowing of the iridocorneal angle associated with glaucoma in the English Springer Spaniel. Vet Ophthalmol. 2002;5(1):49-54.
Oliver JAC, Ekiri A, Mellersh CS. Prevalence of pectinate ligament dysplasia and associations with age, sex and intraocular pressure in the Basset hound, Flatcoated retriever and Dandie Dinmont terrier. Canine Genet Epidemiol. 2016;3:1.
Kato K, Sasaki N, Matsunaga S, Mochizuki M, Nishimura R, Ogawa H. Possible association of glaucoma with pectinate ligament dysplasia and narrowing of the iridocorneal angle in Shiba Inu dogs in Japan. Vet Ophthalmol. 2006;9(2):71-75.
Dubin AJ, Bentley E, Buhr KA, Miller PE. Evaluation of potential risk factors for development of primary angle-closure glaucoma in Bouviers des Flandres. J Am Vet Med Assoc. 2017;250(1):60-67.
Samuelson D, Streit A. Microanatomy of the anterior uveoscleral outflow pathway in normal and primary open-angle glaucomatous dogs. Vet Ophthalmol. 2012;15(S1):47-53.
Samuelson DA, Gum GG, Gelatt KN. Ultrastructural changes in the aqueous outflow apparatus of beagles with inherited glaucoma. Invest Ophthalmol Vis Sci. 1989;30(3):550-561.
Weinreb RN, Robinson MR, Dibas M, Stamer WD. Matrix metalloproteinases and glaucoma treatment. J Ocul Pharmacol Ther. 2020;36(4):208-228.
Gabelt BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res. 2005;24(5):612-637.
Toris CB, Camras CB, Yablonski ME. Effects of PhXA41, a new prostaglandin F2 alpha analog, on aqueous humor dynamics in human eyes. Ophthalmology. 1993;100(9):1297-1304.
Toris CB, Camras CB, Yablonski ME, Brubaker RF. Effects of exogenous prostaglandins on aqueous humor dynamics and blood-aqueous barrier function. Surv Ophthalmol. 1997;41(S2):S69-S75.
Lindsey JD, Kashiwagi K, Kashiwagi F, Weinreb RB. Prostaglandins alter extracellular matix adjacent to human ciliary muscle cells in vitro. Invest Ophthalmol Vis Sci. 1997;38(11):2214-2223.
Kuchtey J, Kuchtey RW. The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure. J Ocul Pharmacol Ther. 2014;30(2-3):170-180.
Powell S, Irnaten M, O’Brien C. Glaucoma - a stiff eye in a stiff body. Curr Eye Res. 2022;48:152-160.
Hart H, Samuelson DA, Tajwar H, et al. Immunolocalization of myocilin protein in the anterior eye of normal and primary open-angle glaucomatous dogs. Vet Ophthalmol. 2007;10(S1):28-37.
MacKay EO, Kallberg ME, Barrie KP, et al. Myocilin protein levels in the aqueous humor of the glaucomas in selected canine breeds. Vet Ophthalmol. 2008;11(4):234-241.
Mackay EO, Kallberg ME, Gelatt KN. Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma Beagles. Vet Ophthalmol. 2008;11(3):177-185.
Oliver JAC, Wright H, Massidda PA, Burmeister LM, Mellersh CS. A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom. Vet Ophthalmol. 2020;23(1):25-36.
Wang H, Li M, Zhang Z, Xue H, Chen X, Ji Y. Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork. Int J Mol Med. 2019;43(2):671-681.
Alexander JP, Samples JR, Acott TS. Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Curr Eye Res. 1998;17(3):276-285.
Alexander JP, Samples JR, Van Buskirk EM, et al. Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork. Invest Ophthalmol Vis Sci. 1991;32(1):172-180.
Huang SH, Adamis AP, Wiederschain DG, et al. Matrix metalloproteinases and their inhibitors in aqueous humor. Exp Eye Res. 1996;62:481-490.
Weinstein WL, Dietrich UM, Sapienza JS, Carmichael KP, Moore PA, Krunkosky TM. Identification of ocular matrix metalloproteinases present within the aqueous humor and iridocorneal drainage angle tissue of normal and glaucomatous canine eyes. Vet Ophthalmol. 2007;10(S1):108-116.
Nga AD, Yap SL, Samsudin A, et al. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma - a quantitative study. BMC Ophthalmol. 2014;14:33.
Chen Y, Yan H, Li G, Zhang Y. Higher TGF-β1, TGF-β2, MMP-2 and TIMP-1 levels in the aqueous humor of the patients with acute primary angle closure. Ophthalmic Res. 2021;64(1):62-67.
Qian T, Fu M, Hu C, Zhang Z, Xu X, Zou H. Imbalance of matrix metalloproteinases and their inhibitors is correlated with trabeculectomy outcomes in acute primary angle closure. Am J Ophthalmol. 2020;212:144-152.
Pumphrey SA, Zitek-Morrison E, Pizzirani S, Meola DM. Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma. Am J Vet Res. 2021;83(3):245-255.
Maatta M, Tervahartiala T, Harju M, et al. Matrix metalloproteinases and their tissue inhibitors in aqueous humor of patients with primary open-angle glaucoma, exfoliation syndrome, and exfoliation glaucoma. J Glaucoma. 2005;14(1):64-69.
Schlotzer-Schrehardt U, Lommatzsch J, Kuchle M, et al. Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2003;44(3):1117-1125.
Bauer BS, Sandmeyer LS, Philibert H, Feng CX, Grahn BH. Chronic glaucoma in dogs: relationships between histologic lesions and the gonioscopic diagnosis of pectinate ligament dysplasia. Vet Pathol. 2016;53(6):1197-1203.
Kuchtey J, Olson LM, Rinkoski T, et al. Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open-angle glaucoma. PLoS Genet. 2011;7(2):e1001306.
Bonafe GA, Boschiero MN, Sodre AR, Ziegler JV, Rocha T, Ortega MM. Natural plant compounds: does caffeine, dipotassium glycyrrhizinate, curcumin, and euphol play roles as antitumoral compounds in glioblastoma cell lines? Front Neurol. 2022;12:784330.
Rudra DS, Pal U, Chowdhury N, Maiti NC, Bagchi A, Swarnakar S. Omeprazole prevents stress induced gastric ulcer by direct inhibition of MMP-2/TIMP-3 interactions. Free Radic Biol Med. 2022;181:221-234.
Siddiqui AJ, Gustafsson T, Sylven C, Crisby M. Rosuvastatin inhibits TIMP-2 and promotes myocardial angiogenesis. Pharmacology. 2014;93(3-4):178-184.
Watanabe M, Ida Y, Ohguro H, Ota C, Hikage F. Diverse effects of pan-ROCK and ROCK2 inhibitors on 2 D and 3D cultured human trabecular meshwork (HTM) cells treated with TGFβ2. Sci Rep. 2021;11(1):15286.
Alshanwani AR, Hagar H, Shaheen S, et al. A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and balancing matrix metalloproteinases. Eur J Pharmacol. 2022;923:174910.
Wei C, Zhang Y, Zhong X, et al. Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways. Chin Med. 2022;17(1):25.
Ashworth Briggs EL, Toh T, Eri R, Hewitt AW, Cook AL. TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients. Mol Vis. 2015;21:1162-1172.
Fountoulakis N, Labiris G, Aristeidou A, et al. Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance. BMC Ophthalmol. 2013;13:69.
Kee C, Son S, Ahn BH. The relationship between gelatinase A activity in aqueous humor and glaucoma. J Glaucoma. 1999;8(1):51-55.
Murphy G. Tissue inhibitors of metalloproteinases. Genome Biol. 2011;12(11):233.
Anthony TL, Lindsey JD, Weinreb RN. Latanoprost's effects on TIMP-1 and TIMP-2 expression in human ciliary muscle cells. Invest Ophthalmol Vis Sci. 2002;43(12):3705-3711.
Yamada H, Yoneda M, Gosho M, Kato T, Zako M. Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases. BMC Ophthalmol. 2016;16:26.
Pradhan ZS, Dalvi RA, Lai T, Kranemann C, Boyd S, Birt CM. Prostaglandin agonist effect on matrix metalloproteinase aqueous levels in glaucoma patients. Can J Ophthalmol. 2015;50(1):6-10.
Konstas AG, Koliakos GG, Karabatsas CH, et al. Latanoprost therapy reduces the levels of TGF beta 1 and gelatinases in the aqueous humour of patients with exfoliative glaucoma. Exp Eye Res. 2006;82:319-322.
Dibas A, Yorio T. Glucocorticoid therapy and ocular hypertension. Eur J Pharmacol. 2016;787:57-71.
Snyder RW, Stamer WD, Kramer TR, Seftor REB. Corticosteroid treatment and trabecular meshwork proteases in cell and organ culture supernatants. Exp Eye Res. 1993;57:461-468.
Mohd Nasir NA, Agarwal R, Krasilnikova A, Sheikh Abdul Kadir SH, Iezhitsa I. Effect of dexamethasone on the expression of MMPs, adenosine A1 receptors and NFKB by human trabecular meshwork cells. J Basic Clin Physiol Pharmacol. 2020;31(6):20190373.
Samples JR, Alexander JP, Acott TS. Regulation of the levels of human trabecular matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasone. Invest Ophthalmol Vis Sci. 1993;34(12):3386-3395.
Ehrich D, Tripathi B, Tripathi R, Duncker G. Effects of interleukin-1beta and dexamethasone on the expression of matrix metalloprotease mRNA by trabecular cells exposed to elevated hydrostatic pressure. Acta Ophthalmol Scand. 2005;83(1):104-108.
Gelatt KN, Mackay EO. The ocular hypertensive effects of topical 0.1% dexamethasone in beagles with inherited glaucoma. J Ocul Pharmacol Ther. 1998;14(1):57-66.
El-Shabrawi Y, Eckhardt M, Berghold A, et al. Synthesis pattern of matrix metalloproteinases (MMPs) and inhibitors (TIMPs) in human explant organ cultures after treatment with latanoprost and dexamethasone. Eye. 2000;14(3A):375-383.
Watanabe M, Ida Y, Furuhashi M, Tsugeno Y, Ohguro H, Hikage F. Screening of the drug-induced effects of prostaglandin EP2 and FP agonists on 3D cultures of dexamethasone-treated human trabecular meshwork cells. Biomedicine. 2021;9(8):930.
Pinard CL, Gauvin D, Moreau M, Martel-Pelletier J, Pelletier J-P, Troncy E. Measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis. Vet Ophthalmol. 2011;14(5):296-303.
Chen H, Zhang G, Chen H, Li L, Xu Z, Xu L. Evaluations of aqueous humor protein markers in different types of glaucoma. Medicine. 2022;101(41):e31048.
Yamamoto Y, Mukai A, Ikushima T, et al. Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model. Sci Rep. 2020;10(1):20936.
Abarca EM, Garcia GA, Moreno N, Rodriguez A. Histopathological features and pattern of expression of MMPS and TIMPS in encapsulated filtering blebs surrounding Ahmed gonioimplant in the dog. Vet Ophthalmol. 2010;13(6):415.
Palko JR, Morris HJ, Pan X, et al. Influence of age on ocular biomechanical properties in a canine glaucoma model with ADAMTS10 mutation. PloS One. 2016;11(6):e0156466.
Leary KA, Lin KT, Steibel JP, Harman CD, Komáromy AM. Safety and efficacy of topically administered netarsudil (Rhopressa) in normal and glaucomatous dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG). Vet Ophthalmol. 2021;24(S1):75-86.
Birch HL. Extracellular matrix and ageing. Subcell Biochem. 2018;90:169-190.