Imaging features to distinguish posterior fossa ependymoma subgroups.

Brain neoplasms Child Ependymoma Fourth ventricle Magnetic resonance imaging

Journal

European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774

Informations de publication

Date de publication:
02 Sep 2023
Historique:
received: 08 02 2023
accepted: 12 07 2023
revised: 03 07 2023
medline: 4 9 2023
pubmed: 4 9 2023
entrez: 2 9 2023
Statut: aheadofprint

Résumé

Posterior fossa ependymoma group A (EPN_PFA) and group B (EPN_PFB) can be distinguished by their DNA methylation and give rise to different prognoses. We compared the MRI characteristics of EPN_PFA and EPN_PFB at presentation. Preoperative imaging of 68 patients with posterior fossa ependymoma from two centers was reviewed by three independent readers, blinded for histomolecular grouping. Location, tumor extension, tumor volume, hydrocephalus, calcifications, tissue component, enhancement or diffusion signal, and histopathological data (cellular density, calcifications, necrosis, mitoses, vascularization, and microvascular proliferation) were compared between the groups. Categorical data were compared between groups using Fisher's exact tests, and quantitative data using Mann-Whitney tests. We performed a Benjamini-Hochberg correction of the p values to account for multiple tests. Fifty-six patients were categorized as EPN_PFA and 12 as EPN_PFB, with median ages of 2 and 20 years, respectively (p = 0.0008). The median EPN_PFA tumoral volume was larger (57 vs 29 cm Morphological characteristics from imaging differ between posterior fossa ependymoma subtypes and may help to distinguish them preoperatively. This study provides a tool to differentiate between group A and group B ependymomas, which will ultimately allow the therapeutic strategy to be adapted in the early stages of patient management. • Posterior fossa ependymoma subtypes often have different imaging characteristics. • Posterior fossa ependymomas group A are commonly median or lateral tissular calcified masses, with incomplete enhancement, affecting young children and responsible for pronounced hydrocephalus and invasion of the posterior fossa foramina. • Posterior fossa ependymomas group B are commonly median non-calcified masses of adolescents and adults, predominantly cystic, and minimally invasive, with total and homogeneous enhancement.

Identifiants

DOI: 10.1007/s00330-023-10182-5 PMID: 37658900
pubmed: 37658900
doi: 10.1007/s00330-023-10182-5
pii: 10.1007/s00330-023-10182-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to European Society of Radiology.

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Auteurs

Thomas Leclerc (T)

Pediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Université Paris Cité, INSERM U1299, Paris, France.
UMR 1163, Institut Imagine, Université Paris Cité, Paris, France.

Raphael Levy (R)

Pediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Université Paris Cité, INSERM U1299, Paris, France.
UMR 1163, Institut Imagine, Université Paris Cité, Paris, France.

Arnault Tauziède-Espariat (A)

Neuropathology Department, GHU Paris, Université Paris Cité, Paris, France.

Charles-Joris Roux (CJ)

Pediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Université Paris Cité, INSERM U1299, Paris, France.
UMR 1163, Institut Imagine, Université Paris Cité, Paris, France.

Kevin Beccaria (K)

Pediatric Neurosurgery Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
Université Paris Cité, Paris, France.

Thomas Blauwblomme (T)

Pediatric Neurosurgery Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
Université Paris Cité, Paris, France.

Stéphanie Puget (S)

Pediatric Neurosurgery Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.

Jacques Grill (J)

Department of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.

Christelle Dufour (C)

Department of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.

Léa Guerrini-Rousseau (L)

Department of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.

Samuel Abbou (S)

Department of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.

Stéphanie Bolle (S)

Department of Radiotherapy Oncology, Gustave Roussy, Villejuif, France.

Alexandre Roux (A)

Neurosurgery Department, GHU Paris, Université Paris Cité, Paris, France.

Johan Pallud (J)

Neurosurgery Department, GHU Paris, Université Paris Cité, Paris, France.

Corentin Provost (C)

Neuroradiology Department, GHU Paris, Université Paris Cité, Paris, France.
INSERM U1266, Institut de Psychiatrie Et Neurosciences de Paris, Université Paris Cité, Paris, France.

Catherine Oppenheim (C)

Neuroradiology Department, GHU Paris, Université Paris Cité, Paris, France.
INSERM U1266, Institut de Psychiatrie Et Neurosciences de Paris, Université Paris Cité, Paris, France.

Pascale Varlet (P)

Neuropathology Department, GHU Paris, Université Paris Cité, Paris, France.
INSERM U1266, Institut de Psychiatrie Et Neurosciences de Paris, Université Paris Cité, Paris, France.

Nathalie Boddaert (N)

Pediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Université Paris Cité, INSERM U1299, Paris, France.
UMR 1163, Institut Imagine, Université Paris Cité, Paris, France.

Volodia Dangouloff-Ros (V)

Pediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France. volodia.dangouloff-ros@aphp.fr.
Université Paris Cité, INSERM U1299, Paris, France. volodia.dangouloff-ros@aphp.fr.
UMR 1163, Institut Imagine, Université Paris Cité, Paris, France. volodia.dangouloff-ros@aphp.fr.
ORCID: 0000-0003-1260-5886

Classifications MeSH